Clinical phase II and III studies of an AS03‐adjuvanted H5N1 influenza vaccine produced in an EB66® cell culture platform
Sign Up to like & getrecommendations! Published in 2020 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.12755
Abstract: We have developed an AS03‐adjuvanted H5N1 influenza vaccine produced in an EB66® cell culture platform (KD‐295). read more here.
Keywords: influenza vaccine; as03 adjuvanted; vaccine produced; adjuvanted h5n1 ... See more keywords
Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01557-17
Abstract: ABSTRACT To study the influenza virus determinants of pathogenicity, we characterized two highly pathogenic avian H5N1 influenza viruses isolated in Vietnam in 2012 (A/duck/Vietnam/QT1480/2012 [QT1480]) and 2013 (A/duck/Vietnam/QT1728/2013 [QT1728]) and found that the activity of… read more here.
Keywords: influenza viruses; virulence; polymerase; h5n1 influenza ... See more keywords
Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2017.00267
Abstract: Infections with lethal influenza viruses lead to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), which may be related to the activation of the host's immune system. Here, in our study, male C57BL/6… read more here.
Keywords: mice infected; distress syndrome; acute respiratory; respiratory distress ... See more keywords
In silico characterization of aryl benzoyl hydrazide derivatives as potential inhibitors of RdRp enzyme of H5N1 influenza virus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1004255
Abstract: RNA-dependent RNA polymerase (RdRp) is a potential therapeutic target for the discovery of novel antiviral agents for the treatment of life-threatening infections caused by newly emerged strains of the influenza virus. Being one of the… read more here.
Keywords: benzoyl hydrazide; h5n1 influenza; hydrazide derivatives; aryl benzoyl ... See more keywords
Aerosolized Exposure to H5N1 Influenza Virus Causes Less Severe Disease Than Infection via Combined Intrabronchial, Oral, and Nasal Inoculation in Cynomolgus Macaques
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13020345
Abstract: Infection with highly pathogenic avian H5N1 influenza virus in humans often leads to severe respiratory disease with high mortality. Experimental infection in non-human primates can provide additional insight into disease pathogenesis. However, such a model… read more here.
Keywords: infection; exposure; disease; h5n1 influenza ... See more keywords