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H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity

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Published in 2020 at "Journal of Neurochemistry"

DOI: 10.1111/jnc.15107

Abstract: Pathological features of Parkinson's disease include the formation of Lewy bodies containing α‐synuclein and the accumulation of iron in the substantia nigra. Previous studies have suggested that iron accumulation contributes to the Parkinson's disease pathology… read more here.

Keywords: aggregation; h63d hfe; h63d; pathology ... See more keywords