H727 cells are inherently resistant to the proteasome inhibitor carfilzomib, yet require proteasome activity for cell survival and growth
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DOI: 10.1038/s41598-019-40635-1
Abstract: The second-in-class proteasome inhibitor (PI) carfilzomib (Kyprolis, Cfz) has contributed to a substantial advancement in multiple myeloma treatment by improving patient survival and quality of life. A considerable portion of patients however display intrinsic resistance… read more here.
Keywords: cfz; h727 cells; proteasome inhibitor; inhibitor carfilzomib ... See more keywords