mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials.
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DOI: 10.1016/j.vaccine.2019.04.074
Abstract: BACKGROUND We evaluated safety and immunogenicity of the first mRNA vaccines against potentially pandemic avian H10N8 and H7N9 influenza viruses. METHODS Two randomized, placebo-controlled, double-blind, phase 1 clinical trials enrolled participants between December 2015 and… read more here.
Keywords: healthy adults; influenza viruses; mrna vaccines; clinical trials ... See more keywords
Specific Monoclonal Antibodies Targeting Unique HA Epitopes Block H7N9 Influenza A Viral Replication
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DOI: 10.1128/jvi.01238-22
Abstract: In 2013, H7N9 influenza viruses appeared in China and other countries resulting in more than 1,500 individual infections or death. There are still limited studies on vaccines or drugs for humans against H7N9 influenza viruses.… read more here.
Keywords: influenza viruses; h7n9 influenza; h7n9; 4h1e8 7h9a6 ... See more keywords
Identification of two residues within the NS1 of H7N9 influenza A virus that critically affect the protein stability and function
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DOI: 10.1186/s13567-018-0594-y
Abstract: The emerging avian-origin H7N9 influenza A virus, which causes mild to lethal human respiratory disease, continues to circulate in China, posing a great threat to public health. Influenza NS1 protein plays a key role in… read more here.
Keywords: protein; influenza virus; h7n9 influenza; virus ... See more keywords
Closure of live bird markets leads to the spread of H7N9 influenza in China
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DOI: 10.1371/journal.pone.0208884
Abstract: Following the emergence of H7N9 influenza in March 2013, local animal and public health authorities in China have been closing live bird markets as a measure to try to control the H7N9 influenza epidemic. The… read more here.
Keywords: bird markets; h7n9 influenza; live bird; closure ... See more keywords
Analysis of the Codon Usage Pattern of HA and NA Genes of H7N9 Influenza A Virus
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DOI: 10.3390/ijms21197129
Abstract: Novel H7N9 influenza virus transmitted from birds to human and, since March 2013, it has caused five epidemic waves in China. Although the evolution of H7N9 viruses has been investigated, the evolutionary changes associated with… read more here.
Keywords: usage pattern; codon usage; codon; influenza virus ... See more keywords