Newcastle disease virus (NDV) recombinant expressing the hemagglutinin of H7N9 avian influenza virus protects chickens against NDV and highly pathogenic avian influenza A (H7N9) virus challenges.
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DOI: 10.1016/j.vaccine.2017.10.010
Abstract: The emerged highly pathogenic avian influenza A (H7N9) (HPAI) viruses in China pose a dual challenge to public health and poultry industry. Thus H7N9 vaccines are in an urgent need. In this study, we constructed… read more here.
Keywords: avian influenza; h7n9 virus; highly pathogenic; h7n9 ... See more keywords
V292I Mutation in PB2 Polymerase Induces Increased Effects of E627K on Influenza H7N9 Virus Replication in Cells.
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DOI: 10.1016/j.virusres.2020.198186
Abstract: Characterization of host adaptation markers among human isolates is important for recognizing the potential for cross-species transmission in avian influenza A viruses. Here, we studied two new potential adaptive mutations, V292I and D740A, in the… read more here.
Keywords: pb2; h7n9 virus; h7n9; polymerase ... See more keywords
The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage
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DOI: 10.1038/s41598-017-02598-z
Abstract: A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627… read more here.
Keywords: h7n9 virus; influenza h7n9; lineage; h7n9 ... See more keywords
Adaptation of influenza A (H7N9) virus in primary human airway epithelial cells
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DOI: 10.1038/s41598-017-10749-5
Abstract: Influenza A (H7N9) is an emerging zoonotic pathogen with pandemic potential. To understand its adaptation capability, we examined the genetic changes and cellular responses following serial infections of A (H7N9) in primary human airway epithelial… read more here.
Keywords: primary human; h7n9 virus; human airway; influenza h7n9 ... See more keywords
Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection
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DOI: 10.1038/s41598-017-17497-6
Abstract: Patients who survive influenza A (H7N9) virus infection are at risk of physical and psychological complications of lung injury and multi-organ dysfunction. However, there were no prospectively individualized assessments of physiological, functional and quality-of-life measures… read more here.
Keywords: h7n9 virus; influenza h7n9; long term; h7n9 ... See more keywords
Will China’s H7N9 Control Strategy Continue to Be Effective?
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DOI: 10.1093/ofid/ofz258
Abstract: Abstract Since the first outbreak of avian influenza A(H7N9) virus in China in early 2013, several interventions to control the transmission of H7N9 virus from poultry to humans have been implemented. Temporarily closing live poultry… read more here.
Keywords: h7n9 virus; control; china h7n9; h7n9 ... See more keywords
Reassortment with Dominant Chicken H9N2 Influenza Virus Contributed to the Fifth H7N9 Virus Human Epidemic
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DOI: 10.1128/jvi.01578-20
Abstract: Avian H9N2 influenza virus, although primarily restricted to chicken populations, is a major threat to human public health by acting as a donor of variant viral genes through reassortment to cocirculating influenza viruses. We established… read more here.
Keywords: influenza virus; virus; h9n2 virus; h7n9 virus ... See more keywords
Comparison of the Efficacy of N9 Neuraminidase-Specific Monoclonal Antibodies against Influenza A(H7N9) Virus Infection
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DOI: 10.1128/jvi.01588-17
Abstract: ABSTRACT The fifth wave of A(H7N9) virus infection in China from 2016 to 2017 caused great concern due to the large number of individuals infected, the isolation of drug-resistant viruses, and the emergence of highly… read more here.
Keywords: h7n9; monoclonal antibodies; h7n9 virus; virus infection ... See more keywords
Erratum to: Population seroprevalence of antibody to influenza A(H7N9) virus, Guangzhou, China
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DOI: 10.1186/s12879-017-2359-z
Abstract: Background: Since the identification in early 2013 of severe disease caused by influenza A(H7N9) virus infection, there have been few attempts to characterize the full severity profile of human infections. Our objective was to estimate… read more here.
Keywords: h7n9 virus; influenza h7n9; antibody; virus ... See more keywords
Increase in Human Infections with Avian Influenza A(H7N9) Virus During the Fifth Epidemic — China, October 2016–February 2017
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DOI: 10.15585/mmwr.mm6609e2
Abstract: During March 2013-February 24, 2017, annual epidemics of avian influenza A(H7N9) in China resulted in 1,258 avian influenza A(H7N9) virus infections in humans being reported to the World Health Organization (WHO) by the National Health… read more here.
Keywords: avian influenza; h7n9 virus; influenza h7n9; h7n9 ... See more keywords
Epidemiological and molecular analysis of avian influenza A(H7N9) virus in Shanghai, China, 2013–2017
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DOI: 10.2147/idr.s179517
Abstract: Background Human infections with a novel avian influenza A virus (H7N9) were reported in Shanghai municipality, China, at the beginning of 2013. High-pathogenic avian influenza (HPAI) H7N9 virus emerged in late February 2017 along with… read more here.
Keywords: avian influenza; h7n9 virus; influenza; h7n9 ... See more keywords