Maduramicin induces cardiotoxicity via Rac1 signaling‐independent methuosis in H9c2 cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4175
Abstract: Maduramicin frequently induces severe cardiotoxicity in target and nontarget animals in clinic. Apoptotic and non‐apoptotic cell death mediate its cardiotoxicity; however, the underlying non‐apoptotic cell death induced by maduramicin remains unclear. In current study, a… read more here.
Keywords: h9c2 cells; cardiotoxicity; h9c2; methuosis ... See more keywords
Neferine attenuates doxorubicin‐induced fibrosis and hypertrophy in H9c2 cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23054
Abstract: Doxorubicin (DOX), an anthracycline antineoplastic candidate is used to treat various malignancies. Around 41% of patients undergoing DOX treatment develop acute cardiotoxicity. Preventing DOX‐induced cardiac fibrosis and hypertrophy helps in evading cardiac remodeling leading to… read more here.
Keywords: hypertrophy; fibrosis hypertrophy; dox; h9c2 ... See more keywords
Pinoresinol diglucoside ameliorates H/R‐induced injury of cardiomyocytes by regulating miR‐142‐3p and HIF1AN
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23175
Abstract: This study is aimed to investigate the effect of pinoresinol diglucoside (PDG) in ameliorating myocardial ischemia–reperfusion injury (MIRI). Hypoxia/reperfusion (H/R)‐induced H9c2 cardiomyocytes were used to establish an in‐vitro ischemia–reperfusion injury model of cardiomyocytes. Cells were… read more here.
Keywords: 142 hif1an; injury; h9c2; mir 142 ... See more keywords
CDK4/6 inhibitor protects against myocardial cells apoptosis by inhibiting RB phosphorylation in H9c2 cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.01.015
Abstract: Cell cycle dysregulation is typical in human cancers, and CDK4/6 inhibitors targeting cell cycle have potential antiapoptosis effect. The aim of this work is to identify the regulatory effect of Palbociclib on apoptosis of H9c2… read more here.
Keywords: cdk4 inhibitor; h9c2 cells; protects myocardial; h9c2 ... See more keywords
Cobalt chloride induces RhoA/ROCK activation and remodeling effect in H9c2 cardiomyoblasts: Involvement of PI3K/Akt and MAPK pathways.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.04.013
Abstract: Chronic heart failure is a serious complication of myocardial infarction, one of the major causes of death worldwide that often leads to adverse cardiac hypertrophy and poor prognosis. Hypoxia-induced cardiac tissue remodeling is considered an… read more here.
Keywords: akt mapk; h9c2; rhoa rock; pi3k akt ... See more keywords
Triterpenoid saponins from Ilex cornuta protect H9c2 cardiomyocytes against H2O2-induced apoptosis by modulating Ezh2 phosphorylation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113691
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Ilex cornuta Lindl. et Paxt. (Aquifoliaceae family) belongs to the Ilex genus. The leaves of this plant are used for the popular herbal tea "Ku-Ding-Cha" in China due to their health benefits for… read more here.
Keywords: ilex cornuta; apoptosis; h9c2; h2o2 induced ... See more keywords
Quantitative proteomic analysis reveals high interference on protein expression of H9c2 cells activated with glucose and cardiotonic steroids.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103536
Abstract: In recent decades, the incidence of death and morbidity due to diabetes has increased worldwide, causing a high social and economic impact. Diabetes is a major cause of blindness, kidney failure, heart attack, stroke and… read more here.
Keywords: protein; h9c2 cells; cells activated; expression ... See more keywords
lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by targeting the miR-122-5p/FOXP2 axis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2019.101500
Abstract: OBJECTIVE To investigate the effect of lncRNA XIST on apoptosis induced by hypoxia. METHODS We analyzed the expression levels of lncRNA XIST and miR-122-5p using RT-qPCR in hypoxia-induced cardiomyocytes. The mechanism by which lncRNA XIST… read more here.
Keywords: expression; h9c2; mir 122; cell ... See more keywords
Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.02.008
Abstract: OBJECTIVE To investigate the novel role of Paraoxonase 2 (PON2) in modulating acute myocardial ischemia-reperfusion injury (IRI). APPROACH IRI was induced both in vivo and ex vivo in male, C57BL6/J (WT) and PON2-deficient (PON-def) mice.… read more here.
Keywords: pi3k; h9c2; mice; acute myocardial ... See more keywords
Suppression of Stim1 reduced intracellular calcium concentration and attenuated hypoxia/reoxygenation induced apoptosis in H9C2 cells
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20171249
Abstract: Objective: Previous studies have demonstrated Stromal interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) contributes to intracellular Ca2+ accumulation. The present study aimed to investigate the expression of STIM1 and its downstream molecules Orai1/TRPC1 in… read more here.
Keywords: apoptosis; suppression stim1; stim1; h9c2 cardiomyocytes ... See more keywords
Ozone attenuated H9c2 cell injury induced by doxorubicin.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001043
Abstract: ABSTRACT Doxorubicin (DOX) is a commonly used drug in the treatment of cancers, while its application in clinical stage is restricted due to side-effects such as cardiomyocyte injury. Increasing studies indicated that ozone may protect… read more here.
Keywords: fold changes; injury; h9c2; ozone ... See more keywords