Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.05.009
Abstract: To unveil the possible protective role of isorhamnetin, an immediate 3'-O-methylated metabolite of quercetin, in cardiomyocyte under hypoxia/reoxygenation (H/R) condition and the underlying mechanisms involved, H9c2 cardiomyocytes were exposed to the vehicle or H/R for… read more here.
Keywords: h9c2 cardiomyocytes; induced injure; isorhamnetin; apoptosis ... See more keywords
A polysaccharide of Dendrobium officinale ameliorates H2O2-induced apoptosis in H9c2 cardiomyocytes via PI3K/AKT and MAPK pathways.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.169
Abstract: Dendrobium officinale is one valuable traditional Chinese medicine, which has skyscraping medicinal value. Polysaccharide is the main active ingredient in D. officinale; its antioxidant activity is a hot research topic nowadays. Oxidative stress plays an… read more here.
Keywords: apoptosis; pi3k akt; h9c2 cardiomyocytes; akt mapk ... See more keywords
Suppression of Stim1 reduced intracellular calcium concentration and attenuated hypoxia/reoxygenation induced apoptosis in H9C2 cells
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20171249
Abstract: Objective: Previous studies have demonstrated Stromal interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) contributes to intracellular Ca2+ accumulation. The present study aimed to investigate the expression of STIM1 and its downstream molecules Orai1/TRPC1 in… read more here.
Keywords: apoptosis; suppression stim1; stim1; h9c2 cardiomyocytes ... See more keywords
The protective effect of lipid emulsion in preventing bupivacaine-induced mitochondrial injury and apoptosis of H9C2 cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery"
DOI: 10.1080/10717544.2016.1261379
Abstract: Abstract Lipid emulsion (LE) has been shown to be effective in the resuscitation of bupivacaine-induced cardiac arrest, but the precise mechanism of this action has not been fully elucidated. Pursuant to this lack of information… read more here.
Keywords: bupivacaine induced; h9c2 cardiomyocytes; bupivacaine; apoptosis h9c2 ... See more keywords
Induced pluripotent stem cell‐conditional medium inhibits H9C2 cardiomyocytes apoptosis via autophagy flux and Wnt/β‐catenin pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14327
Abstract: Induced pluripotent stem cell‐derived conditioned medium (iPS‐CM) could improve cell viability in many types of cells and may be a better alternative for the treatment of myocardial infarction. This study aimed to examine the influence… read more here.
Keywords: h9c2 cardiomyocytes; stem cell; pathway; pluripotent stem ... See more keywords
Protective Effect of Fasudil on Hydrogen Peroxide-Induced Oxidative Stress Injury of H9C2 Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2021 at "Disease Markers"
DOI: 10.1155/2021/8177705
Abstract: Objective Oxidative damage is a pathological factor that causes cardiovascular damage in the clinic and is increasingly serious. This study focused on the effect of fasudil on H2O2-induced oxidative damage in cardiomyocytes. Materials and Methods… read more here.
Keywords: h2o2; group; h2o2 group; h9c2 cardiomyocytes ... See more keywords
Forsythiaside Protected H9c2 Cardiomyocytes from H2O2-Induced Oxidative Stress and Apoptosis via Activating Nrf2/HO-1 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2022 at "International heart journal"
DOI: 10.1536/ihj.21-585
Abstract: Forsythiaside, one of the main bioactive components of Chinese medicine Lian Qiao, exerts antioxidant, anti-bacterial, and anti-inflammatory effects. To date, the mechanism of Forsythiaside in cardiomyocyte injury remains unclear. However, the antioxidant effects of Forsythiaside… read more here.
Keywords: apoptosis; h9c2 cells; oxidative stress; h9c2 cardiomyocytes ... See more keywords
Ranolazine exhibits anti-inflammatory and antioxidant activities in H9c2 cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202304_31927
Abstract: OBJECTIVE The aim of this study was to evaluate the effectiveness of ranolazine on hypoxia-inducible factor-1α (HIF-1α) and oxidative stress in H9c2 cardiomyocyte cells. MATERIALS AND METHODS We have assessed the effects of increasing concentrations… read more here.
Keywords: oxidative stress; antioxidant capacity; markers decreased; h9c2 cardiomyocytes ... See more keywords
MicroRNA-194-5p attenuates hypoxia/reoxygenation-induced apoptosis in H9C2 cardiomyocytes by inhibiting the over-activation of RAC1 protein
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12920
Abstract: Ras-related C3 botulinum toxin substrate 1 (RAC1), a member of the Rac family of guanosine triphosphate phosphohydrolases, has been suggested to be a regulator of myocardial injury during ischemia and reperfusion (I/R). Whether microRNAs (miRs)… read more here.
Keywords: apoptosis h9c2; hypoxia reoxygenation; apoptosis; rac1 ... See more keywords
Montelukast protects H9c2 cardiomyocytes against radiation-induced toxicity
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Medical Science"
DOI: 10.5114/aoms/122734
Abstract: Background: As we know, high levels of oxidation are also reflected by elevated levels of NADPH oxidase-4 (NOX-4) and malondialdehyde (MDA), which are known to contribute to many disease processes. And Radiation-induced cardiotoxicity is a… read more here.
Keywords: montelukast; radiation; protects h9c2; montelukast protects ... See more keywords