Temporal effect of melatonin posttreatment on anoxia/reoxygenation injury in H9c2 cells
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DOI: 10.1002/cbin.11759
Abstract: Melatonin has been proven to reduce myocardial ischemia‐reperfusion (MI/R) injury. However, in most studies, melatonin was administered before MI/R, thus, the results lack clinical significance in patients with acute myocardial infarction. We hypothesize that melatonin… read more here.
Keywords: reoxygenation; h9c2 cells; melatonin posttreatment; injury ... See more keywords
Maduramicin induces cardiotoxicity via Rac1 signaling‐independent methuosis in H9c2 cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4175
Abstract: Maduramicin frequently induces severe cardiotoxicity in target and nontarget animals in clinic. Apoptotic and non‐apoptotic cell death mediate its cardiotoxicity; however, the underlying non‐apoptotic cell death induced by maduramicin remains unclear. In current study, a… read more here.
Keywords: h9c2 cells; cardiotoxicity; h9c2; methuosis ... See more keywords
Preventive effect of apigenin against isoproterenol‐induced apoptosis in cardiomyoblasts
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DOI: 10.1002/jbt.22213
Abstract: We investigated the effect of apigenin, a dietary flavonoid, on isoproterenol hydrochloride (ISO)‐induced apoptotic signaling in cardiomyoblast H9C2 cells. The results showed that apigenin treatment (10 µM) prevented ISO (31.25 μM)‐induced lipid peroxidative levels and antioxidants status… read more here.
Keywords: effect apigenin; h9c2 cells; isoproterenol; effect ... See more keywords
Schizandrin protects H9c2 cells against lipopolysaccharide‐induced injury by downregulating Smad3
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22301
Abstract: Schizandrin is a major bioactive constituent of Schisandra chinensis (Turcz.) Baill with antioxidant and anti‐inflammatory properties. The objective of this study was to explore the potential effects of schizandrin on a cell model of myocarditis.… read more here.
Keywords: h9c2 cells; downregulating smad3; induced injury; schizandrin ... See more keywords
DUSP12 ameliorates myocardial ischemia–reperfusion injury through HSPB8‐induced mitophagy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23310
Abstract: This study aimed to explore the role of dual specificity phosphatase 12 (DUSP12) in regulating myocardial ischemia–reperfusion (I/R) injury and the underlying mechanism. The expression of DUSP12 in myocardial tissues and heat‐shock protein beta‐8 (HSPB8)… read more here.
Keywords: hspb8; h9c2 cells; myocardial ischemia; myocardial tissues ... See more keywords
Long noncoding RNA TALNEC2 regulates myocardial ischemic injury in H9c2 cells by regulating miR‐21/PDCD4‐medited activation of Wnt/β‐catenin pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28562
Abstract: The goal of this study was to explore the role of tumor associated long noncoding RNA expressed on chromosome 2 (TALNEC2) in protecting against myocardial ischemic injury, as well as its underlying molecular mechanism. We… read more here.
Keywords: h9c2 cells; talnec2; injury; wnt catenin ... See more keywords
Ginsenoside Rg1 protects H9c2 cells against nutritional stress‐induced injury via aldolase /AMPK/PINK1 signalling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29150
Abstract: Insufficient nutrients supply will greatly affect the function of cardiac myocytes. The adaptive responses of cardiac myocytes to nutritional stress are not fully known. Ginsenoside Rg1 is one of the most pharmacologically active components in… read more here.
Keywords: ginsenoside rg1; h9c2 cells; aldolase; nutritional stress ... See more keywords
Protective effects of agrimonolide on hypoxia-induced H9c2 cell injury by maintaining mitochondrial homeostasis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30169
Abstract: Cardiomyocyte death caused by hypoxia is one of the main causes of myocardial infarction or heart failure, and mitochondria play an important role in this process. Agrimonolide (AM) is a monomeric component extracted from Agrimonia… read more here.
Keywords: h9c2 cells; induced h9c2; cell; hypoxia induced ... See more keywords
miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology letters"
DOI: 10.1007/s10529-020-03013-w
Abstract: miRNAs have been pointed to play critical role in the development of congenital heart disease (CHD). miRNA-375-3p (miR-375-3p) was involved in cardiac dysfunction and cardiogenesis. However, no prior study had established a therapeutic role of… read more here.
Keywords: h9c2 cells; apoptosis; bcl2l2; mir 375 ... See more keywords
Azoramide improves mitochondrial dysfunction in palmitate-induced insulin resistant H9c2 cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03590-z
Abstract: Azoramide is identified as a new compound with the dual properties for the improvement of ER-folding capacity in various cells as well as for the treatment of T2DM. Although the effect of azoramide in glucose-homeostasis… read more here.
Keywords: insulin; h9c2 cells; treatment; insulin resistant ... See more keywords
Protective Effect of Morphine Against the Oxidant-Induced Injury in H9c2 Cells
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DOI: 10.1007/s12012-018-9448-0
Abstract: There are some indications that morphine may exert myocardial protective effects under certain conditions. The aim of the present study was to investigate the effect of morphine on viability and oxidative state of H9c2 cells… read more here.
Keywords: morphine; h9c2 cells; effect morphine; gsk ... See more keywords