Enhanced Survival and Accelerated Perfusion of Skin Flap to Recipient Site Following Administration of Human α1-Antitrypsin in Murine Models.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in wound care"
DOI: 10.1089/wound.2018.0889
Abstract: Objective: Skin flaps are routinely used in reconstructive surgery yet remain susceptible to ischemia and necrosis. Distant flaps require lengthy time to detach causing patient discomfort. Human α1-antitrypsin (hAAT) is a clinically available serum glycoprotein.… read more here.
Keywords: haat; administration; perfusion; skin flap ... See more keywords
S-Nitrosylation of α1-Antitrypsin Triggers Macrophages Toward Inflammatory Phenotype and Enhances Intra-Cellular Bacteria Elimination
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DOI: 10.3389/fimmu.2019.00590
Abstract: Background: Human α1-antitrypsin (hAAT) is a circulating anti-inflammatory serine-protease inhibitor that rises during acute phase responses. in vivo, hAAT reduces bacterial load, without directly inhibiting bacterial growth. In conditions of excess nitric-oxide (NO), hAAT undergoes… read more here.
Keywords: bacteria elimination; antitrypsin; nitrosylation; haat ... See more keywords
Accelerated Wound Border Closure Using a Microemulsion Containing Non-Inhibitory Recombinant α1-Antitrypsin
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DOI: 10.3390/ijms23137364
Abstract: Wound healing requires a non-compromising combination of inflammatory and anti-inflammatory processes. Human α1-antitrypsin (hAAT), a circulating glycoprotein that rises during acute-phase responses and during healthy pregnancies, is tissue-protective and tolerance-inducing; although anti-inflammatory, hAAT enhances revascularization.… read more here.
Keywords: microemulsion; wound healing; antitrypsin; haat ... See more keywords