Abnormal functional connectivity of the habenula in mild cognitive impairment patients with depression symptoms revealed by resting‐state functional magnetic resonance imaging
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.5910
Abstract: Recent research suggests that abnormalities in the habenula (HB), a core area of the brain that transmits reward information, may be a determinant of depression. However, it is not clear whether the functional connectivity (FC)… read more here.
Keywords: depression symptoms; mild cognitive; depression; habenula ... See more keywords
Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Human brain mapping"
DOI: 10.1002/hbm.26337
Abstract: Understanding the evolutionarily conserved feature of functional laterality in the habenula has been attracting attention due to its potential role in human cognition and neuropsychiatric disorders. Deciphering the structure of the human habenula remains to… read more here.
Keywords: heterogeneity; brain; habenula; human brain ... See more keywords
Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.01.003
Abstract: BACKGROUND The ability to appropriately integrate and respond to rewarding and aversive stimuli is essential for survival. The ventral pallidum (VP) plays a critical role in processing both rewarding and aversive stimuli. However, the VP… read more here.
Keywords: reward seeking; constrain reward; glutamatergic neurons; habenula ... See more keywords
The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.108054
Abstract: Summary Operant learning requires multiple cognitive processes, such as learning, prediction of potential outcomes, and decision-making. It is less clear how interactions of these processes lead to the behavioral adaptations that allow animals to cope… read more here.
Keywords: zebrafish dorsolateral; updating learned; habenula; habenula required ... See more keywords
Behavior: Local Lateral Habenula Interneurons Mediate Aggression
Sign Up to like & getrecommendations! Published in 2020 at "Current Biology"
DOI: 10.1016/j.cub.2020.06.065
Abstract: A recent study has shown that local inhibitory GAD2-positive neurons regulate the activity of lateral habenula neurons, thereby governing aggressive behavior in male mice. read more here.
Keywords: behavior local; habenula; habenula interneurons; local lateral ... See more keywords
Habenula-prefrontal resting-state connectivity in reactive aggressive men – A pilot study
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.10.025
Abstract: Disproportionate anger and reactive aggression in response to provocation are core symptoms of intermittent-explosive disorder (IED). Previous research shows a link between the propensity for aggression in healthy individuals and altered functioning of prefrontal-limbic and… read more here.
Keywords: aggressive men; habenula; aggression; reactive aggressive ... See more keywords
The Lateral Habenula and Adaptive Behaviors
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2017.06.001
Abstract: The evolutionarily conserved lateral habenula (LHb) enables dynamic responses to continually changing contexts and environmental conditions. A model is proposed to account for greater mnemonic and contextual control over LHb-mediated response flexibility as vertebrate brains… read more here.
Keywords: response; lhb; habenula; habenula adaptive ... See more keywords
Magnetic susceptibility imaging of human habenula at 3 T
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-75733-y
Abstract: The habenula plays an important role in brain reward circuitry and psychiatric conditions. While much work has been done on the function and structure of the habenula in animal models, in vivo imaging studies of… read more here.
Keywords: human habenula; susceptibility; habenula; imaging human ... See more keywords
Kisspeptin-1 regulates forebrain dopaminergic neurons in the zebrafish
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-75777-0
Abstract: The habenula is a phylogenetically conserved epithalamic structure, which conveys negative information via inhibition of mesolimbic dopamine neurons. We have previously shown the expression of kisspeptin (Kiss1) in the habenula and its role in the… read more here.
Keywords: dopamine; habenula; neurons zebrafish; dopaminergic neurons ... See more keywords
Involvement of the habenula in the pathophysiology of autism spectrum disorder
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00603-0
Abstract: The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of social interactions, behavioral adaptation, sensory… read more here.
Keywords: disorder; involvement habenula; habenula; habenula pathophysiology ... See more keywords
Association between habenula dysfunction and motivational symptoms in unmedicated major depressive disorder
Sign Up to like & getrecommendations! Published in 2017 at "Social Cognitive and Affective Neuroscience"
DOI: 10.1093/scan/nsx074
Abstract: Abstract The lateral habenula plays a central role in reward and punishment processing and has been suggested to drive the cardinal symptom of anhedonia in depression. This hypothesis is largely based on observations of habenula… read more here.
Keywords: depression; punishment; habenula dysfunction; habenula ... See more keywords