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   Articles with "habenula" as a keyword



Potassium Release From the Habenular Astrocytes Induces Depressive‐Like Behaviors in Mice

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recommendations! Published in 2024 at "Glia"

DOI: 10.1002/glia.24647

Abstract: The habenula has been implicated in psychiatric disorders such as depression, primarily because of its role in the modulation of the dopaminergic and serotonergic systems, which play a role in the pathophysiology of these disorders.… read more here.

Keywords: habenula; potassium release; habenular astrocytes; potassium ... See more keywords

Abnormal functional connectivity of the habenula in mild cognitive impairment patients with depression symptoms revealed by resting‐state functional magnetic resonance imaging

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recommendations! Published in 2023 at "International Journal of Geriatric Psychiatry"

DOI: 10.1002/gps.5910

Abstract: Recent research suggests that abnormalities in the habenula (HB), a core area of the brain that transmits reward information, may be a determinant of depression. However, it is not clear whether the functional connectivity (FC)… read more here.

Keywords: depression symptoms; mild cognitive; depression; habenula ... See more keywords
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Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.

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recommendations! Published in 2023 at "Human brain mapping"

DOI: 10.1002/hbm.26337

Abstract: Understanding the evolutionarily conserved feature of functional laterality in the habenula has been attracting attention due to its potential role in human cognition and neuropsychiatric disorders. Deciphering the structure of the human habenula remains to… read more here.

Keywords: heterogeneity; brain; habenula; human brain ... See more keywords

Glutamatergic Ventral Pallidal Neurons Modulate Activity of the Habenula–Tegmental Circuitry and Constrain Reward Seeking

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recommendations! Published in 2018 at "Biological Psychiatry"

DOI: 10.1016/j.biopsych.2018.01.003

Abstract: BACKGROUND The ability to appropriately integrate and respond to rewarding and aversive stimuli is essential for survival. The ventral pallidum (VP) plays a critical role in processing both rewarding and aversive stimuli. However, the VP… read more here.

Keywords: reward seeking; constrain reward; glutamatergic neurons; habenula ... See more keywords
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The Zebrafish Dorsolateral Habenula Is Required for Updating Learned Behaviors

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recommendations! Published in 2020 at "Cell Reports"

DOI: 10.1016/j.celrep.2020.108054

Abstract: Summary Operant learning requires multiple cognitive processes, such as learning, prediction of potential outcomes, and decision-making. It is less clear how interactions of these processes lead to the behavioral adaptations that allow animals to cope… read more here.

Keywords: zebrafish dorsolateral; updating learned; habenula; habenula required ... See more keywords
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Behavior: Local Lateral Habenula Interneurons Mediate Aggression

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recommendations! Published in 2020 at "Current Biology"

DOI: 10.1016/j.cub.2020.06.065

Abstract: A recent study has shown that local inhibitory GAD2-positive neurons regulate the activity of lateral habenula neurons, thereby governing aggressive behavior in male mice. read more here.

Keywords: behavior local; habenula; habenula interneurons; local lateral ... See more keywords

Habenula-prefrontal resting-state connectivity in reactive aggressive men – A pilot study

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recommendations! Published in 2019 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2018.10.025

Abstract: Disproportionate anger and reactive aggression in response to provocation are core symptoms of intermittent-explosive disorder (IED). Previous research shows a link between the propensity for aggression in healthy individuals and altered functioning of prefrontal-limbic and… read more here.

Keywords: aggressive men; habenula; aggression; reactive aggressive ... See more keywords
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The Lateral Habenula and Adaptive Behaviors

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recommendations! Published in 2017 at "Trends in Neurosciences"

DOI: 10.1016/j.tins.2017.06.001

Abstract: The evolutionarily conserved lateral habenula (LHb) enables dynamic responses to continually changing contexts and environmental conditions. A model is proposed to account for greater mnemonic and contextual control over LHb-mediated response flexibility as vertebrate brains… read more here.

Keywords: response; lhb; habenula; habenula adaptive ... See more keywords

The disappointment centre of the brain gets exciting: a systematic review of habenula dysfunction in depression

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recommendations! Published in 2024 at "Translational Psychiatry"

DOI: 10.1038/s41398-024-03199-x

Abstract: Background The habenula is an epithalamic brain structure that acts as a neuroanatomical hub connecting the limbic forebrain to the major monoamine centres. Abnormal habenula activity is increasingly implicated in depression, with a surge in… read more here.

Keywords: dysfunction depression; brain; habenula; depression ... See more keywords

Sex-specific habenular dysconnectivity in patients with late-life depression

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recommendations! Published in 2025 at "Translational Psychiatry"

DOI: 10.1038/s41398-025-03329-z

Abstract: There are significant sex differences in the prevalence, symptom presentation, treatment response and brain abnormalities of patients with late-life depression (LLD). The functional connectivity of the habenula has been associated with depressive symptoms and cognitive… read more here.

Keywords: patients late; habenula; gyrus; late life ... See more keywords

Magnetic susceptibility imaging of human habenula at 3 T

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-75733-y

Abstract: The habenula plays an important role in brain reward circuitry and psychiatric conditions. While much work has been done on the function and structure of the habenula in animal models, in vivo imaging studies of… read more here.

Keywords: human habenula; susceptibility; habenula; imaging human ... See more keywords