Metformin inhibits pro‐inflammatory responses via targeting nuclear factor‐κB in HaCaT cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3367
Abstract: Psoriasis is a prevalent, chronic inflammatory skin disease that arises from rapid and excessive growth of keratinocytes induced by abnormal inflammatory responses. Metformin is the first‐line drug in type 2 diabetes and has been proven… read more here.
Keywords: inflammatory responses; metformin inhibits; hacat cells; factor ... See more keywords
The role of human immortal skin keratinocytes‐acellular dermal matrix scaffold in skin repair and regeneration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28588
Abstract: In this study, we aimed to investigate the phenotypic characteristics of human immortal skin keratinocytes (HaCaT) cells and the role of acellular dermal matrix (ADM) in coculture system of HaCaT cells and ADM. Flow cytometry… read more here.
Keywords: skin; hacat cells; role; human immortal ... See more keywords
Protective skin aging effects of cherry blossom extract (Prunus Yedoensis) on oxidative stress and apoptosis in UVB-irradiated HaCaT cells
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0215-7
Abstract: Extracts of the cherry blossom plant have been reported to exert various biological effects on human cells. However, no previous investigations have examined the antioxidant and anti-apoptotic effects of these extracts on ultraviolet B (UVB)… read more here.
Keywords: apoptosis; skin aging; cbe; cherry blossom ... See more keywords
Ar-Turmerone Exerts Anti-proliferative and Anti-inflammatory Activities in HaCaT Keratinocytes by Inactivating Hedgehog Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation"
DOI: 10.1007/s10753-019-01131-w
Abstract: Psoriasis, a common skin inflammatory disorder, is characterized by the aberrant growth and differentiation of keratinocytes. Ar-Turmerone, a main bioactive ingredient of Curcuma longa , has been found to alleviate skin inflammation in psoriasis-like mice.… read more here.
Keywords: turmerone; hedgehog pathway; inflammatory; hacat cells ... See more keywords
Transcriptomic profiles of human HaCaT cells in response to angelica polysaccharide
Sign Up to like & getrecommendations! Published in 2019 at "3 Biotech"
DOI: 10.1007/s13205-019-1828-z
Abstract: The aim of this study was to explore the anti-psoriatic effect and potential mechanism of Angelica polysaccharide (APS) on an in vitro HaCaT cell model. MTS assay was performed to determine whether APS has the… read more here.
Keywords: angelica polysaccharide; group; proliferation; hacat cells ... See more keywords
Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biological Chemistry"
DOI: 10.1007/s13765-018-0377-1
Abstract: Excessive accumulation of reactive oxygen species (ROS) during oxidative stress accelerates the skin aging process. ROS stimulate inflammatory processes in the skin, leading to activation of matrix metalloprotease-1 (MMP-1). Silent information regulator 1 (SIRT1) controls… read more here.
Keywords: sirt1; collagen; sirt1 activation; hacat cells ... See more keywords
Sudachitin, a polymethoxyflavone from Citrus sudachi, induces apoptosis via the regulation of MAPK pathways in human keratinocyte HaCaT cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.010
Abstract: Although we recently reported that sudachitin (5,7,4'-trihydroxy-6,8,3'-trimethoxyflavone), a polymethoxyflavone isolated from the peel of Citrus sudachi, can induce apoptosis in human keratinocyte HaCaT cells, the mechanism underlying its action remains unclear. In this study, we… read more here.
Keywords: keratinocyte hacat; citrus sudachi; polymethoxyflavone; hacat cells ... See more keywords
A novel glyceroglycolipid from brown algae Ishige okamurae improve photoaging and counteract inflammation in UVB-induced HaCaT cells.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109737
Abstract: BACKGROUND Excessive exposure to Ultraviolet (UV) rays can cause premature skin aging. Ishigoside (IGS) is a new glyceroglycolipid compound isolated from brown algal Ishige okamurae, However, whether it can protect the skin from (Ultraviolet-B) UVB… read more here.
Keywords: uvb induced; hacat cells; induced hacat; ishige okamurae ... See more keywords
Oncostatin M sensitizes keratinocytes to UVB-induced inflammation via GSDME-mediated pyroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2021.09.004
Abstract: BACKGROUND Oncostatin M (OSM), an interleukin-6 (IL-6) family proinflammatory cytokine, plays a critical role in inflammatory skin diseases, but its mechanism of action is not well understood. OBJECTIVE To demonstrate the mechanism of OSM induced… read more here.
Keywords: induced inflammation; gsdme; hacat cells; uvb induced ... See more keywords
Topical treatments of Saussurea costus root and Thuja orientalis L. synergistically alleviate atopic dermatitis-like skin lesions by inhibiting protease-activated receptor-2 and NF-κB signaling in HaCaT cells and Nc/Nga mice.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.01.055
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The root of Saussurea costus (Aucklandia lappa Decne, Aucklandiae Radix, SC) and Thuja orientalis L. (TOL) have been traditionally used as anti-inflammatory agents in Korea. However, they have not been studied for the… read more here.
Keywords: hacat cells; tol; nga mice; dorsal skin ... See more keywords
Cathelicidin-NV from Nanorana ventripunctata effectively protects HaCaT cells, ameliorating ultraviolet B-induced skin photoaging
Sign Up to like & getrecommendations! Published in 2022 at "Peptides"
DOI: 10.1016/j.peptides.2021.170712
Abstract: Cathelicidins are diverse effector molecules in the vertebrate immune system and are related to immune regulation, inflammatory response, wound healing, and blood vessel formation. However, little is known about their free radical scavenging ability, especially… read more here.
Keywords: nanorana ventripunctata; cathelicidin; induced skin; skin photoaging ... See more keywords