The Glycolysis‐derived α‐Dicarbonyl Metabolite Methylglyoxal is a UVA‐photosensitizer Causing the Photooxidative Elimination of HaCaT Keratinocytes with Induction of Oxidative and Proteotoxic Stress Response Gene Expression †
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13717
Abstract: Cellular oxidative stress contributes to solar ultraviolet (UV) radiation‐induced skin photoaging and photocarcinogenesis. Light‐driven electron and energy transfer reactions involving non‐DNA chromophores are a major source of reactive oxygen species (ROS) in skin, and the… read more here.
Keywords: stress; uva photosensitizer; stress response; hacat keratinocytes ... See more keywords
Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes
Sign Up to like & getrecommendations! Published in 2018 at "Biological Research"
DOI: 10.1186/s40659-018-0181-8
Abstract: BackgroundPsoriasis is a complex, chronic inflammatory skin disease with substantial negative effects on patient quality of life. Long non-coding RNAs (lncRNAs) are able to be involved in multitudes of cellular processes in diverse human diseases.… read more here.
Keywords: hacat keratinocytes; lncrna mir31hg; keratinocytes proliferation; mir31hg ... See more keywords
Antioxidant Effects of Korean Propolis in HaCaT Keratinocytes Exposed to Particulate Matter 10
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DOI: 10.3390/antiox11040781
Abstract: Air pollution causes oxidative stress that leads to inflammatory diseases and premature aging of the skin. The purpose of this study was to examine the antioxidant effect of Korean propolis on oxidative stress in human… read more here.
Keywords: hacat keratinocytes; exposed particulate; fraction; keratinocytes exposed ... See more keywords
Syringaresinol Inhibits UVA-Induced MMP-1 Expression by Suppression of MAPK/AP-1 Signaling in HaCaT Keratinocytes and Human Dermal Fibroblasts
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DOI: 10.3390/ijms21113981
Abstract: Ultraviolet (UV) irradiation induces detrimental changes in human skin which result in photoaging. UV-induced intracellular changes cause degradation of extracellular matrix (ECM). UV-stimulated cleavage of collagen in ECM occurs via matrix metalloproteinases (MMPs). (±)-syringaresinol (SYR),… read more here.
Keywords: uva induced; production; hacat keratinocytes; syr ... See more keywords
Fucoidan Isolated from Sargassum confusum Suppresses Inflammatory Responses and Oxidative Stress in TNF-α/IFN-γ- Stimulated HaCaT Keratinocytes by Activating Nrf2/HO-1 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20020117
Abstract: Recent studies have revealed that marine brown seaweeds contain numerous bioactive compounds which exhibit various bioactivities. The present study investigated the effect of low molecular weight fucoidan (SCF) isolated from Sargassum confusum, a brown alga,… read more here.
Keywords: inflammatory responses; tnf ifn; tnf; ifn stimulated ... See more keywords
Amauroderma rugosum Extract Suppresses Inflammatory Responses in Tumor Necrosis Factor Alpha/Interferon Gamma-Induced HaCaT Keratinocytes
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DOI: 10.3390/molecules27196533
Abstract: Keratinocytes form the physical barrier of the skin and play an important role in the inflammatory process. Amauroderma rugosum is an edible mushroom; however, its pharmacological properties have seldom been studied. Although the anti-inflammatory effect… read more here.
Keywords: hacat keratinocytes; rugosum; amauroderma rugosum; rugosum extract ... See more keywords
Optimized High-Content Imaging Screening Quantifying Micronuclei Formation in Polymer-Treated HaCaT Keratinocytes
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DOI: 10.3390/nano12244463
Abstract: Research on nano- and micro-plastic particles (NMPPs) suggests their potential threat to human health. Some studies have even suggested genotoxic effects of NMPP exposure, such as micronuclei (MN) formation, while others found the opposite. To… read more here.
Keywords: micronuclei formation; content imaging; optimized high; high content ... See more keywords
Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of coptisine against oxidative stress-induced DNA damage and apoptosis in HaCaT keratinocytes.
Sign Up to like & getrecommendations! Published in 2019 at "General physiology and biophysics"
DOI: 10.4149/gpb_2019014
Abstract: In this study, the protective effect of coptisine on the oxidative damage-mediated apoptosis was evaluated in cultured human HaCaT keratinocytes. The results demonstrate that preincubation of cells with coptisine prior to H2O2 stimulation resulted in… read more here.
Keywords: apoptosis; hacat keratinocytes; coptisine oxidative; h2o2 ... See more keywords