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   Articles with "hace2" as a keyword



Effects of simeprevir on the replication of SARS-CoV-2 in vitro and in transgenic hACE2 mice

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recommendations! Published in 2021 at "International Journal of Antimicrobial Agents"

DOI: 10.1016/j.ijantimicag.2021.106499

Abstract: In a bid to contain the current COVID-19 (coronavirus disease 2019) pandemic, various countermeasures have been applied. To date, however, there is a lack of an effective drug for the treatment of COVID-19. Through molecular… read more here.

Keywords: hace2; sars cov; effects simeprevir; transgenic hace2 ... See more keywords

A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2

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recommendations! Published in 2021 at "Virology"

DOI: 10.1016/j.virol.2020.10.002

Abstract: Nisin, a food-grade antimicrobial peptide produced by lactic acid bacteria has been examined for its probable interaction with the human ACE2 (hACE2) receptor, the site where spike protein of SARS-CoV-2 binds. Among the eight nisin… read more here.

Keywords: nisin; hace2; spike protein; receptor ... See more keywords

The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry

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recommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-021-00604-5

Abstract: Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global pandemic. The spike (S) protein of etiologic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specifically recognizes human angiotensin-converting enzyme 2 (hACE2) as… read more here.

Keywords: hace2; exosomal hace2; interferon; virus entry ... See more keywords
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Establishment of a humanized swine model for COVID-19

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recommendations! Published in 2021 at "Cell Discovery"

DOI: 10.1038/s41421-021-00313-x

Abstract: Dear Editor, Currently, wild-type (WT) hamsters, ferrets, cats, and non-human primates are being used as COVID-19 animal models. However, no severe clinical symptoms develop in these animals. Similarly, most of the human ACE2 (hACE2) transgenic… read more here.

Keywords: pig; hace2; covid; model ... See more keywords
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Inhalable nanocatchers for SARS-CoV-2 inhibition

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recommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2102957118

Abstract: Significance The recently emerged SARS-CoV-2 variants are more transmissible, which brings new challenges to vaccine treatment. There is an urgent global need for alternative strategies that could effectively and rapidly prevent the infection of various… read more here.

Keywords: hace2; inhibition; formulation; hace2 containing ... See more keywords

Molecular dynamics analysis predicts ritonavir and naloxegol strongly block the SARS-CoV-2 spike protein-hACE2 binding

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recommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2020.1830854

Abstract: Abstract The rapid emergence of COVID-19 pandemics has posed humans particularly vulnerable to the novel SARS-CoV-2 virus. Since de novo drug discovery is both expensive and time-consuming, drug repurposing approaches are believed to be of… read more here.

Keywords: analysis; hace2; sars cov; protein ... See more keywords

hACE2 upregulation and participation of macrophages and clear cells in the immune response of epididymis to SARS‐CoV‐2 in K18‐hACE2 mice

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recommendations! Published in 2024 at "Andrology"

DOI: 10.1111/andr.13755

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus caused the coronavirus disease 2019 pandemic, and the prevalence of deaths among men is higher than among women. The epididymis, divided into caput, corpus, and cauda,… read more here.

Keywords: sars cov; epididymis; k18 hace2; hace2 upregulation ... See more keywords

Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0272019

Abstract: Coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is currently spreading globally. To overcome the COVID-19 pandemic, preclinical evaluations of vaccines and therapeutics using K18-hACE2 and CAG-hACE2 transgenic mice are ongoing.… read more here.

Keywords: k18 hace2; hace2; cag hace2; hace2 mice ... See more keywords
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Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2

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recommendations! Published in 2021 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1009683

Abstract: COVID-19 is a global crisis of unimagined dimensions. Currently, Remedesivir is only fully licensed FDA therapeutic. A major target of the vaccine effort is the SARS-CoV-2 spike-hACE2 interaction, and assessment of efficacy relies on time… read more here.

Keywords: cell fusion; hace2; fusion assay; sars cov ... See more keywords

Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.1055811

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike protein infects the host by binding to angiotensin-converting enzyme 2 (ACE2) expressed… read more here.

Keywords: k18 hace2; hace2; infection; hace2 mice ... See more keywords

Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model

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recommendations! Published in 2024 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2024.1370511

Abstract: Introduction SARS coronavirus 2 (SARS-CoV-2) infects human angiotensin-converting enzyme 2 (hACE2)-expressing lung epithelial cells through its spike (S) protein. The S protein is highly glycosylated and could be a target for lectins. Surfactant protein A… read more here.

Keywords: sars cov; lung injury; protein; hace2 ... See more keywords