Effects of simeprevir on the replication of SARS-CoV-2 in vitro and in transgenic hACE2 mice
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Antimicrobial Agents"
DOI: 10.1016/j.ijantimicag.2021.106499
Abstract: In a bid to contain the current COVID-19 (coronavirus disease 2019) pandemic, various countermeasures have been applied. To date, however, there is a lack of an effective drug for the treatment of COVID-19. Through molecular… read more here.
Keywords: hace2; sars cov; effects simeprevir; transgenic hace2 ... See more keywords
A natural food preservative peptide nisin can interact with the SARS-CoV-2 spike protein receptor human ACE2
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2020.10.002
Abstract: Nisin, a food-grade antimicrobial peptide produced by lactic acid bacteria has been examined for its probable interaction with the human ACE2 (hACE2) receptor, the site where spike protein of SARS-CoV-2 binds. Among the eight nisin… read more here.
Keywords: nisin; hace2; spike protein; receptor ... See more keywords
The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00604-5
Abstract: Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global pandemic. The spike (S) protein of etiologic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specifically recognizes human angiotensin-converting enzyme 2 (hACE2) as… read more here.
Keywords: hace2; exosomal hace2; interferon; virus entry ... See more keywords
Establishment of a humanized swine model for COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Cell Discovery"
DOI: 10.1038/s41421-021-00313-x
Abstract: Dear Editor, Currently, wild-type (WT) hamsters, ferrets, cats, and non-human primates are being used as COVID-19 animal models. However, no severe clinical symptoms develop in these animals. Similarly, most of the human ACE2 (hACE2) transgenic… read more here.
Keywords: pig; hace2; covid; model ... See more keywords
Inhalable nanocatchers for SARS-CoV-2 inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2102957118
Abstract: Significance The recently emerged SARS-CoV-2 variants are more transmissible, which brings new challenges to vaccine treatment. There is an urgent global need for alternative strategies that could effectively and rapidly prevent the infection of various… read more here.
Keywords: hace2; inhibition; formulation; hace2 containing ... See more keywords
Molecular dynamics analysis predicts ritonavir and naloxegol strongly block the SARS-CoV-2 spike protein-hACE2 binding
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1830854
Abstract: Abstract The rapid emergence of COVID-19 pandemics has posed humans particularly vulnerable to the novel SARS-CoV-2 virus. Since de novo drug discovery is both expensive and time-consuming, drug repurposing approaches are believed to be of… read more here.
Keywords: analysis; hace2; sars cov; protein ... See more keywords
Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0272019
Abstract: Coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is currently spreading globally. To overcome the COVID-19 pandemic, preclinical evaluations of vaccines and therapeutics using K18-hACE2 and CAG-hACE2 transgenic mice are ongoing.… read more here.
Keywords: k18 hace2; hace2; cag hace2; hace2 mice ... See more keywords
Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009683
Abstract: COVID-19 is a global crisis of unimagined dimensions. Currently, Remedesivir is only fully licensed FDA therapeutic. A major target of the vaccine effort is the SARS-CoV-2 spike-hACE2 interaction, and assessment of efficacy relies on time… read more here.
Keywords: cell fusion; hace2; fusion assay; sars cov ... See more keywords
Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1055811
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike protein infects the host by binding to angiotensin-converting enzyme 2 (ACE2) expressed… read more here.
Keywords: k18 hace2; hace2; infection; hace2 mice ... See more keywords
The Tissue Distribution of SARS-CoV-2 in Transgenic Mice With Inducible Ubiquitous Expression of hACE2
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.821506
Abstract: The novel coronavirus disease COVID-19 has become one of the most socially significant infections. One of the main models for COVID-19 pathogenesis study and anti-COVID-19 drug development is laboratory animals sensitive to the virus. Herein,… read more here.
Keywords: expression; hace2; sars cov; mice ... See more keywords
Phage Display-Derived Compounds Displace hACE2 from Its Complex with SARS-CoV-2 Spike Protein
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020441
Abstract: Severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious beta-class coronavirus. Although vaccinations have shown high efficacy, the emergence of novel variants of concern (VOCs) has already exhibited traits of immune evasion. Thus, the development… read more here.
Keywords: hace2; spike protein; phage display; sars cov ... See more keywords