The Infection and Pathogenicity of SARS-CoV-2 Variant B.1.351 in hACE2 Mice
Sign Up to like & getrecommendations! Published in 2021 at "Virologica Sinica"
DOI: 10.1007/s12250-021-00452-1
Abstract: Since the outbreak of COVID-19 at the end of 2019, its causative agent SARS-CoV-2 has been spreading around the world for one and half a year. During the long global circulation of SARS-CoV-2, mutations in… read more here.
Keywords: hace2 mice; infection; 351 variant; mice ... See more keywords
The severity of SARS-CoV-2 infection in K18-hACE2 mice is attenuated by a novel steroid-derivative in a gender-specific manner.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16155
Abstract: BACKGROUND AND PURPOSE COVID-19 infections caused by SARS-CoV-2 disseminate through human-to-human transmission can evoke severe inflammation. Treatments to reduce the SARS-CoV-2-associated inflammation are needed and are the focus of much research. In this study, we… read more here.
Keywords: k18 hace2; infection; hace2 mice; severity ... See more keywords
Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice
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DOI: 10.1371/journal.pone.0272019
Abstract: Coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is currently spreading globally. To overcome the COVID-19 pandemic, preclinical evaluations of vaccines and therapeutics using K18-hACE2 and CAG-hACE2 transgenic mice are ongoing.… read more here.
Keywords: k18 hace2; hace2; cag hace2; hace2 mice ... See more keywords
Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1055811
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike protein infects the host by binding to angiotensin-converting enzyme 2 (ACE2) expressed… read more here.
Keywords: k18 hace2; hace2; infection; hace2 mice ... See more keywords
Characterization of Three Variants of SARS-CoV-2 In Vivo Shows Host-Dependent Pathogenicity in Hamsters, While Not in K18-hACE2 Mice
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DOI: 10.3390/v14112584
Abstract: Animal models are used in preclinical trials to test vaccines, antivirals, monoclonal antibodies, and immunomodulatory drug therapies against SARS-CoV-2. However, these drugs often do not produce equivalent results in human clinical trials. Here, we show… read more here.
Keywords: k18 hace2; animal models; hace2 mice; mice ... See more keywords