1019 – THE EFFECTS OF INFLAMMATION ON HEALTHY AND MALIGNANT HAEMATOPOIESIS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.018
Abstract: Hematopoietic stem cells (HSCs) only function when localised in complex niches within the bone marrow microenvironment, where stroma and haematopoietic cell types cooperate to regulate their function. HSC fate is affected by multiple stresses such… read more here.
Keywords: healthy malignant; haematopoiesis; effects inflammation; inflammation healthy ... See more keywords
Clonal haematopoiesis of emerging significance.
Sign Up to like & getrecommendations! Published in 2021 at "Pathology"
DOI: 10.1016/j.pathol.2021.02.005
Abstract: Clonal haematopoiesis (CH) is a ubiquitous feature of aging and provides mechanistic insight into the inextricable relationship between chronic inflammation and age-related diseases. Although CH confers a cumulative risk of subsequent haematological malignancy, particularly myeloid… read more here.
Keywords: haematopoiesis emerging; clonal haematopoiesis; risk; haematopoiesis ... See more keywords
Disordered haematopoiesis and cardiovascular disease: a focus on myelopoiesis.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical science"
DOI: 10.1042/cs20180111
Abstract: Cardiovascular (CV) diseases (CVD) are primarily caused by atherosclerotic vascular disease. Atherogenesis is mainly driven by recruitment of leucocytes to the arterial wall, where macrophages contribute to both lipid retention as well as the inflammatory… read more here.
Keywords: haematopoiesis; disordered haematopoiesis; disease; cvd ... See more keywords
Application of single-cell RNA sequencing methodologies in understanding haematopoiesis and immunology
Sign Up to like & getrecommendations! Published in 2019 at "Essays in Biochemistry"
DOI: 10.1042/ebc20180072
Abstract: The blood and immune system are characterised by utmost diversity in its cellular components. This heterogeneity can solely be resolved with the application of single-cell technologies that enable precise examination of cell-to-cell variation. Single-cell transcriptomics… read more here.
Keywords: haematopoiesis; cell rna; immunology; cell ... See more keywords
Recent advances in understanding clonal haematopoiesis in aplastic anaemia
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14510
Abstract: Acquired aplastic anaemia (AA) is an immune‐mediated bone marrow failure disorder inextricably linked to clonal haematopoiesis. The majority of AA patients have somatic mutations and/or structural chromosomal abnormalities detected as early as at diagnosis. In… read more here.
Keywords: clonal haematopoiesis; advances understanding; haematopoiesis; aplastic anaemia ... See more keywords
Less iron improves MDS haematopoiesis
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.16012
Abstract: It has been well known for more than a decade, that iron overload adversely affects the prognosis of patients with lower-risk myelodysplastic syndromes (MDS) (Malcovati et al, 2005). Iron overload may be transfusion-related as well… read more here.
Keywords: haematopoiesis; treatment; iron chelation; iron overload ... See more keywords
Extramedullary haematopoiesis presenting as a periportal mass
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Case Reports"
DOI: 10.1136/bcr-2020-235064
Abstract: Extramedullary haematopoiesis (EMH) is defined as haematopoiesis occurring in organs outside the bone marrow. The liver is one of the rare sites of EMH, and to the best of our knowledge, a few cases of… read more here.
Keywords: periportal mass; extramedullary haematopoiesis; haematopoiesis; haematopoiesis presenting ... See more keywords
Emerging patterns in clonal haematopoiesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2019-205851
Abstract: Clonal haematopoiesis (CH) is defined by the presence of acquired mutations and/or cytogenetic abnormalities in haematopoietic cells. By definition, these premalignant clones do not meet criteria for haematopoietic neoplasms listed in the Revised Fourth Edition… read more here.
Keywords: clonal haematopoiesis; emerging patterns; patterns clonal; haematopoiesis ... See more keywords
Unravelling genetic causality of haematopoiesis on bone metabolism in human.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of endocrinology"
DOI: 10.1530/eje-22-0526
Abstract: OBJECTIVE Haematopoiesis was shown to regulate bone metabolism in in vivo studies. However, whether haematopoiesis has causal effects on bone health has never been investigated in human. We aimed to evaluate the causal relationships of… read more here.
Keywords: count beta; blood traits; bone metabolism; blood ... See more keywords
Comprehensive Analysis of Acquired Genetic Variants and Their Prognostic Impact in Systemic Mastocytosis
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DOI: 10.3390/cancers14102487
Abstract: Simple Summary Systemic mastocytosis (SM) is a clonal haematopoietic stem cell disease typically characterized by the expansion and accumulation of neoplastic mast cells carrying the activating KIT D816V as a driver mutation. Multilineage involvement of… read more here.
Keywords: haematopoiesis; kit d816v; mutation; systemic mastocytosis ... See more keywords
New light shed on the early evolution of limb-bone growth plate and bone marrow
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.51581
Abstract: The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent in the fin bones of ray-finned fish. When did long bones start producing blood cells? Recent hypotheses suggested… read more here.
Keywords: haematopoiesis; bone marrow; evolution limb; limb bone ... See more keywords