A Phase 2a dose‐escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS‐986231 in hospitalized patients with heart failure with reduced ejection fraction
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DOI: 10.1002/ejhf.897
Abstract: This study was designed to evaluate the safety, tolerability and haemodynamic effects of BMS‐986231, a novel second‐generation nitroxyl donor with potential inotropic, lusitropic and vasodilatory effects in patients hospitalized with decompensated heart failure and reduced… read more here.
Keywords: heart; effects bms; safety tolerability; heart failure ... See more keywords
Haemodynamic effects of initial combination therapy in pulmonary arterial hypertension: a systematic review and meta-analysis
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DOI: 10.1183/23120541.00313-2022
Abstract: Background Although the initial use of combination treatment has been proven to be beneficial for patients’ clinical outcomes, there are scarce data on its haemodynamic effects. The objective of the present study was to evaluate… read more here.
Keywords: initial combination; haemodynamic effects; combination; therapy ... See more keywords