Mechanisms of 8‐aminoquinoline induced haemolytic toxicity in a G6PDd humanized mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17362
Abstract: Primaquine (PQ) and Tafenoquine (TQ) are clinically important 8‐aminoquinolines (8‐AQ) used for radical cure treatment of P. vivax infection, known to target hepatic hypnozoites. 8‐AQs can trigger haemolytic anaemia in individuals with glucose‐6‐phosphate dehydrogenase deficiency… read more here.
Keywords: mouse model; treatment; haemolytic toxicity; humanized mouse ... See more keywords