A simple clinical tool for effective screening of haemophagocytic lymphohistiocytosis in dengue
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DOI: 10.1007/s15010-025-02542-8
Abstract: Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder. Dengue fever is a common trigger for HLH in the tropics. We aimed to develop a simplified clinical tool to detect HLH in dengue patients. A cross-sectional… read more here.
Keywords: dengue; tool; clinical tool; haemophagocytic lymphohistiocytosis ... See more keywords
Combined emapalumab and ruxolitinib in patients with haemophagocytic Lymphohistiocytosis
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DOI: 10.1038/s41408-024-01056-0
Abstract: the doses of both agents were rather high. read more here.
Keywords: ruxolitinib patients; emapalumab ruxolitinib; combined emapalumab; haemophagocytic lymphohistiocytosis ... See more keywords
EP18 Use of anakinra for haemophagocytic lymphohistiocytosis in adults
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa109.017
Abstract: Haemophagocytic lymphohistiocytosis (HLH) is a rare, life threatening syndrome characterised by severe immune activation. The primary form occurs in early childhood and is fatal without treatment. Secondary HLH can occur at any age, usually in… read more here.
Keywords: secondary hlh; treatment; haemophagocytic lymphohistiocytosis; none ... See more keywords
Etiologies and management of haemophagocytic lymphohistiocytosis: is it time for an updated protocol and targeted treatments?
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DOI: 10.1093/rheumatology/keaa741
Abstract: OBJECTIVE The objective of this study was to analyse the features, therapeutic approaches, and outcomes for adult patients with haemophagocytic lymphohistiocytosis (HLH) at a single centre. METHODS This study was a retrospective chart review of… read more here.
Keywords: 2004 protocol; total patients; haemophagocytic lymphohistiocytosis; hlh 2004 ... See more keywords
How i treat primary haemophagocytic lymphohistiocytosis
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.15274
Abstract: Primary haemophagocytic lymphohistiocytosis (HLH) diseases are a collection of inherited genetic disorders that cause the syndrome of HLH. Great advances have been made in the last 20 years with regard to the discovery of many… read more here.
Keywords: primary haemophagocytic; haemophagocytic lymphohistiocytosis; treat primary; hlh diseases ... See more keywords
Haemophagocytic lymphohistiocytosis and Epstein-Barr virus: a complex relationship with diverse origins, expression and outcomes.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of haematology"
DOI: 10.1111/bjh.17638
Abstract: Epstein-Barr virus (EBV) is a ubiquitous herpesvirus with rare but severe potential for lymphoproliferative complications. EBV is associated with a variety of presentations of haemophagocytic lymphohistiocytosis (HLH). HLH is a life-threatening hyperinflammatory syndrome that can… read more here.
Keywords: ebv; epstein barr; ebv associated; barr virus ... See more keywords
Efficacy and safety of ruxolitinib‐based regimen in the treatment of paediatric Epstein–Barr virus‐associated haemophagocytic lymphohistiocytosis
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DOI: 10.1111/bjh.20264
Abstract: Ruxolitinib (RUX) has demonstrated efficacy in haemophagocytic lymphohistiocytosis (HLH) patients, but large cohort studies regarding its clinical application in children with Epstein–Barr virus‐associated HLH (EBV‐HLH) remain scarce. This retrospective study analysed the efficacy and safety… read more here.
Keywords: treatment; based regimen; efficacy; rux ... See more keywords
Diagnostic impact of exome sequencing in haemophagocytic lymphohistiocytosis: A report from the Italian reference centre
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DOI: 10.1111/bjh.70087
Abstract: Broad analyses like WES were more likely to achieve this goal compared to TR, which is limited to a restricted panel of genes. Despite a common suspicion of HLH, ge-netic diagnoses revealed a spectrum of… read more here.
Keywords: sequencing haemophagocytic; exome sequencing; impact exome; diagnostic impact ... See more keywords
Retrospective single‐centre analysis of diagnostic approach to adult‐onset haemophagocytic lymphohistiocytosis
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DOI: 10.1111/imj.14891
Abstract: Haemophagocytic lymphohistiocytosis (HLH) is a rare disorder with a poor prognosis characterised by substantial immune activation leading to end‐organ failure. In childhood, genetic defects that impair cytotoxic function of natural killer cells and T cells.… read more here.
Keywords: analysis diagnostic; lymphohistiocytosis; centre analysis; retrospective single ... See more keywords
Analysis of the clinical characteristics of lamotrigine‐induced haemophagocytic lymphohistiocytosis
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DOI: 10.1111/jcpt.13602
Abstract: Lamotrigine is currently known to be related to haemophagocytic lymphohistiocytosis (HLH). Knowledge regarding the association between HLH and lamotrigine is mainly based on case reports. The purpose of this study was to evaluate the clinical… read more here.
Keywords: analysis clinical; characteristics lamotrigine; lamotrigine induced; haemophagocytic lymphohistiocytosis ... See more keywords
HHV-8-associated haemophagocytic lymphohistiocytosis in a patient with advanced AIDS
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DOI: 10.1136/bcr-2017-222382
Abstract: We present a patient with advanced AIDS admitted with recurrent shock of unclear aetiology, fevers, altered mental status and refractory cytopenias. His case posed a diagnostic challenge because evaluation of septic shock in the setting… read more here.
Keywords: haemophagocytic lymphohistiocytosis; patient; advanced aids; hlh ... See more keywords