‘Artificial spermatid'-mediated genome editing†
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioz087
Abstract: Abstract For years, extensive efforts have been made to use mammalian sperm as the mediator to generate genetically modified animals; however, the strategy of sperm-mediated gene transfer (SMGT) is unable to produce stable and diversified… read more here.
Keywords: genome editing; haescs; spermatid mediated; mediated genome ... See more keywords
Transcriptome profiles and chromatin states in mouse androgenetic haploid embryonic stem cells.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13436
Abstract: Haploid embryonic stem cells (haESCs) are derived from the inner cell mass of the haploid blastocyst, containing only one set of chromosomes. Extensive and accurate chromatin remodelling occurs during haESC derivation, but the intrinsic transcriptome… read more here.
Keywords: haploid; haescs; transcriptome profiles; stem ... See more keywords
Metabolic reprogramming by itaconate: Haescs-derived therapy targets fibroblast GLUD1 to alleviate ocular graft versus host disease
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-585
Abstract: Backgroud：Ocular chronic graft-versus-host disease (ocGVHD) is a significant complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), with an incidence rate of 40-60%. Its primary manifestations include dry eye syndrome and visual impairment, with severe cases… read more here.
Keywords: metabolic reprogramming; analysis; cell; graft versus ... See more keywords