Overexpression of Matriptase‐1 Inhibitor HAI‐1 as an Effective Strategy to Reduce Proteolytic Clipping in Chinese Hamster Ovary Cells
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DOI: 10.1002/biot.70141
Abstract: Proteolytic degradation of recombinant proteins in Chinese hamster ovary (CHO) cells remains a major challenge in biopharmaceutical manufacturing, often reducing product yield and quality. Matriptase‐1, a type II transmembrane serine protease, has been identified as… read more here.
Keywords: hai; hamster ovary; matriptase; overexpression ... See more keywords
KLK14 interactions with HAI‐1 and HAI‐2 serine protease inhibitors: A molecular dynamics and relative free‐energy calculations study
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DOI: 10.1002/cbin.10839
Abstract: Kallikrein 14 (KLK14) is a serine protease linked to several pathologies including prostate cancer and positively correlates with Gleason score. Though KLK14 functioning in cancer is poorly understood, it has been implicated in HGF/Met signaling,… read more here.
Keywords: hai hai; energy calculations; serine protease; hai ... See more keywords
Increased Survival Benefit of Adjuvant Intra-arterial Infusion Chemotherapy in HCC Patients with Portal Vein Infiltration after Hepatectomy
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DOI: 10.1007/s00268-020-05527-w
Abstract: Background The role of adjuvant hepatic intra-arterial infusion chemotherapy (HAI) is considered to be a promising option. Methods We examined treatment effects of adjuvant HAI using cisplatin in 37 hepatocellular carcinoma (HCC) patients with portal… read more here.
Keywords: hcc; infusion chemotherapy; infiltration; hai ... See more keywords
The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells
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DOI: 10.1038/s41598-017-15415-4
Abstract: Dysregulation of pericellular proteolysis is often required for tumor invasion and cancer progression. It has been shown that down-regulation of hepatocyte growth factor activator inhibitor-2 (HAI-2) results in activation of matriptase (a membrane-anchored serine protease),… read more here.
Keywords: human prostate; prostate cancer; matriptase; hai ... See more keywords
N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity.
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DOI: 10.1093/glycob/cwad002
Abstract: Hepatocyte growth factor activator inhibitor (HAI)-2, is an integral membrane Kunitz-type serine protease inhibitor that regulates the proteolysis of matriptase and prostasin in a cell-type selective manner. The cell-type selective nature of HAI-2 function depends… read more here.
Keywords: glycosylation asn; hai; protease inhibitory; type ... See more keywords
SPINT2 (HAI‐2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI‐2 to inhibit prostasin but not matriptase
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy394
Abstract: Abstract The syndromic form of congenital sodium diarrhea (SCSD) is caused by bi‐allelic mutations in SPINT2, which encodes a Kunitz‐type serine protease inhibitor (HAI‐2). We report three novel SCSD patients, two novel SPINT2 mutations and… read more here.
Keywords: inhibit prostasin; matriptase; hai; sodium diarrhea ... See more keywords
Economic burden of healthcare-associated infections (HAI) in a pediatric hospital in Honduras
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DOI: 10.1093/jpids/piae093.006
Abstract: In numerous reports, the World Health Organization has published that in LMICs approximately 15% of hospitalized patients acquire an HAI. In the Region of the Americas, many countries have made considerable progress in implementing IPC… read more here.
Keywords: hospital; methodology; hais; hai ... See more keywords
P-1784. Reduction of bacterial resistance in isolates from nosocomial infections through a program of antibiotic stewardship based on a local mobile application in a hospital in Mexico City; 10 years of success
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.1947
Abstract: Abstract Background Hospital-acquired infections caused by multidrug-resistant microorganisms (MDR-HAI) are associated with high healthcare costs, prolonged hospital stays, and concerning morbidity and mortality. The prevalence of MDR-HAI has increased worldwide as a result of the… read more here.
Keywords: hospital; rate; mdr hai; application ... See more keywords
A rapid and flexible microneutralization assay for serological assessment of influenza viruses
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DOI: 10.1111/irv.13141
Abstract: Background Serological responses from influenza vaccination or infection are typically measured by Hemagglutinin Inhibition (HAI) or Microneutralization (MN). Both methods are limited in feasibility, standardization, and generalizability. We describe a luciferase MN (LMN) assay that… read more here.
Keywords: microneutralization; h3n2 hong; hong kong; influenza viruses ... See more keywords
A 2-year point-prevalence surveillance of healthcare-associated infections and antimicrobial use in Ferrara University Hospital, Italy
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DOI: 10.1186/s12879-020-4791-8
Abstract: Background Healthcare-Associated Infections (HAIs) represent one of the leading issues to patient safety as well as a significant economic burden. Similarly, Antimicrobial Use (AMU) and Resistance (AMR) represent a growing threat to global public health… read more here.
Keywords: hospital; prevalence; hai; associated infections ... See more keywords
Analysis of a theory of change to evaluate the Health Care-Associated Infection Prevention Program (HAI) in Colombia
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DOI: 10.1186/s12913-024-12072-y
Abstract: Healthcare-associated infections affect the safety of patients, health personnel, and families and generate expenses for health systems. The Theory of Change allows us to evaluate the strengths and weaknesses of a program, hoping to achieve… read more here.
Keywords: theory change; program; prevention; hai ... See more keywords