KLK14 interactions with HAI‐1 and HAI‐2 serine protease inhibitors: A molecular dynamics and relative free‐energy calculations study
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10839
Abstract: Kallikrein 14 (KLK14) is a serine protease linked to several pathologies including prostate cancer and positively correlates with Gleason score. Though KLK14 functioning in cancer is poorly understood, it has been implicated in HGF/Met signaling,… read more here.
Keywords: hai hai; energy calculations; serine protease; hai ... See more keywords
Increased Survival Benefit of Adjuvant Intra-arterial Infusion Chemotherapy in HCC Patients with Portal Vein Infiltration after Hepatectomy
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DOI: 10.1007/s00268-020-05527-w
Abstract: Background The role of adjuvant hepatic intra-arterial infusion chemotherapy (HAI) is considered to be a promising option. Methods We examined treatment effects of adjuvant HAI using cisplatin in 37 hepatocellular carcinoma (HCC) patients with portal… read more here.
Keywords: hcc; infusion chemotherapy; infiltration; hai ... See more keywords
The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells
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DOI: 10.1038/s41598-017-15415-4
Abstract: Dysregulation of pericellular proteolysis is often required for tumor invasion and cancer progression. It has been shown that down-regulation of hepatocyte growth factor activator inhibitor-2 (HAI-2) results in activation of matriptase (a membrane-anchored serine protease),… read more here.
Keywords: human prostate; prostate cancer; matriptase; hai ... See more keywords
N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity.
Sign Up to like & getrecommendations! Published in 2023 at "Glycobiology"
DOI: 10.1093/glycob/cwad002
Abstract: Hepatocyte growth factor activator inhibitor (HAI)-2, is an integral membrane Kunitz-type serine protease inhibitor that regulates the proteolysis of matriptase and prostasin in a cell-type selective manner. The cell-type selective nature of HAI-2 function depends… read more here.
Keywords: glycosylation asn; hai; protease inhibitory; type ... See more keywords
SPINT2 (HAI‐2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI‐2 to inhibit prostasin but not matriptase
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy394
Abstract: Abstract The syndromic form of congenital sodium diarrhea (SCSD) is caused by bi‐allelic mutations in SPINT2, which encodes a Kunitz‐type serine protease inhibitor (HAI‐2). We report three novel SCSD patients, two novel SPINT2 mutations and… read more here.
Keywords: inhibit prostasin; matriptase; hai; sodium diarrhea ... See more keywords
A rapid and flexible microneutralization assay for serological assessment of influenza viruses
Sign Up to like & getrecommendations! Published in 2023 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.13141
Abstract: Background Serological responses from influenza vaccination or infection are typically measured by Hemagglutinin Inhibition (HAI) or Microneutralization (MN). Both methods are limited in feasibility, standardization, and generalizability. We describe a luciferase MN (LMN) assay that… read more here.
Keywords: microneutralization; h3n2 hong; hong kong; influenza viruses ... See more keywords
A 2-year point-prevalence surveillance of healthcare-associated infections and antimicrobial use in Ferrara University Hospital, Italy
Sign Up to like & getrecommendations! Published in 2020 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-020-4791-8
Abstract: Background Healthcare-Associated Infections (HAIs) represent one of the leading issues to patient safety as well as a significant economic burden. Similarly, Antimicrobial Use (AMU) and Resistance (AMR) represent a growing threat to global public health… read more here.
Keywords: hospital; prevalence; hai; associated infections ... See more keywords
The prevalence of healthcare associated infections among adult inpatients at nineteen large Australian acute-care public hospitals: a point prevalence survey
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DOI: 10.1186/s13756-019-0570-y
Abstract: BackgroundAustralia does not have a national healthcare associated infection (HAI) surveillance program. Only one HAI point prevalence study has been undertaken in 1984. The objective of this study was to estimate the burden of healthcare… read more here.
Keywords: infection; prevalence; point prevalence; hai ... See more keywords
Hepatic artery therapies for unresectable colorectal liver metastases: Pooled survival analysis of 968 patients from TACE, yttrium-90, and HAI studies.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.4_suppl.747
Abstract: 747Background: Approximately 140,000 people are newly diagnosed with colorectal cancer (CRC) annually, while 50,000 will die from the disease. Median survival has increased with use of modern chemotherapy and biologic agents. Sixty percent of advanced… read more here.
Keywords: tace yttrium; hai; hepatic artery; artery therapies ... See more keywords
Impact of Primary Tumor Laterality on Adjuvant Hepatic Artery Infusion Pump Chemotherapy in Resected Colon Cancer Liver Metastases: Analysis of 487 Patients
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-020-09369-7
Abstract: Hepatic artery infusion (HAI) chemotherapy is associated with overall survival (OS) in patients with resected colon cancer liver metastases (CLM). The prognostic impact of primary tumor location in CLM following hepatic resection in patients receiving… read more here.
Keywords: laterality; hai; primary tumor; colon cancer ... See more keywords
Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin
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DOI: 10.1371/journal.pone.0192632
Abstract: The membrane-bound serine proteases prostasin and matriptase and the Kunitz-type protease inhibitors HAI-1 and HAI-2 are all expressed in human skin and may form a tightly regulated proteolysis network, contributing to skin pathophysiology. Evidence from… read more here.
Keywords: human skin; skin; matriptase; hai ... See more keywords