The effects of noise‐induced hair cell lesions on cochlear electromechanical responses: A computational approach using a biophysical model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal for Numerical Methods in Biomedical Engineering"
DOI: 10.1002/cnm.3582
Abstract: A biophysically inspired signal processing model of the human cochlea is deployed to simulate the effects of specific noise‐induced inner hair cell (IHC) and outer hair cell (OHC) lesions on hearing thresholds, cochlear compression, and… read more here.
Keywords: noise induced; hair cell; effects noise; model ... See more keywords
Interferon regulatory factor-7 is required for hair cell development during zebrafish embryogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental neurobiology"
DOI: 10.1002/dneu.22860
Abstract: Interferon regulatory factor-7 (IRF7) is an essential regulator of both innate and adaptive immunity. It is also expressed in the otic vesicle of zebrafish embryos. However, any role for irf7 in hair cell development was… read more here.
Keywords: hair cell; cell development; hair; gene ... See more keywords
RBM24 is required for mouse hair cell development through regulating pre‐mRNA alternative splicing and mRNA stability
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.31003
Abstract: As the sensory receptor cells in vertebrate inner ear and lateral lines, hair cells are characterized by the hair bundle that consists of one tubulin‐based kinocilium and dozens of actin‐based stereocilia on the apical surface… read more here.
Keywords: hair; mrna stability; hair cell; cell development ... See more keywords
Essential Role of Sptan1 in Cochlear Hair Cell Morphology and Function Via Focal Adhesion Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02551-2
Abstract: Hearing loss is the most common human sensory deficit. Hearing relies on stereocilia, inserted into the cuticular plate of hair cells (HCs), where they play an important role in the perception of sound and its… read more here.
Keywords: focal adhesion; hair cell; hair; function ... See more keywords
In vivo assay of the ethanol-induced embryonic hair cell loss and the protective role of the retinoic and folic acid in zebrafish larvae (Danio rerio).
Sign Up to like & getrecommendations! Published in 2019 at "Alcohol"
DOI: 10.1016/j.alcohol.2018.07.008
Abstract: In reference to the auditory manifestation of fetal alcohol syndrome, previous work has preferentially focused on the deviant neural development of the auditory system. Changes in the sensory hair cell, the ultimate sensory organ, were… read more here.
Keywords: folic acid; hair cell; hair; cell loss ... See more keywords
Summating potentials from the utricular macula of anaesthetized guinea pigs
Sign Up to like & getrecommendations! Published in 2021 at "Hearing Research"
DOI: 10.1016/j.heares.2021.108259
Abstract: The Summating Potential (SP) was first recorded in the cochlea in the 1950s and represents an objective measure of cochlear hair cell function, in vivo. Despite being a regular tool in hearing research, a similar… read more here.
Keywords: hair cell; anaesthetized guinea; guinea pigs; utricular macula ... See more keywords
Outer hair cell functioning in infants with iron deficiency anemia.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pediatric otorhinolaryngology"
DOI: 10.1016/j.ijporl.2020.110393
Abstract: BACKGROUND Distortion product otoacoustic emissions (DPOAE) in infants with Iron Deficiency Anemia (IDA) helps in understanding the cochlear status especially the functioning of outer hair cells. OBJECTIVES To analyze the presence of DPOAE across frequencies… read more here.
Keywords: outer hair; hair cell; iron deficiency; cell functioning ... See more keywords
Double fluorescent labelling of a bipolar epithelial cell in vitro: The outer hair cell
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2017.10.014
Abstract: BACKGROUND Fluorescence membrane markers are efficient tools for visualizing the dynamics of membrane recycling processes in living cells. The outer hair cell (OHC) - a bipolar epithelial cell in the cochlea - possesses endocytic activity… read more here.
Keywords: apical basal; bipolar epithelial; outer hair; epithelial cell ... See more keywords
Cisplatin-induced vestibular hair cell lesion-less damage at high doses
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Otology"
DOI: 10.1016/j.joto.2018.08.002
Abstract: Cisplatin, a widely used anticancer drug, damages hair cells in cochlear organotypic cultures at low doses, but paradoxically causes little damage at high doses resulting in a U-shaped dose-response function. To determine if the cisplatin… read more here.
Keywords: damage high; hair cell; hair; cisplatin ... See more keywords
Electron cryo-tomography of vestibular hair-cell stereocilia.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2019.02.006
Abstract: High-resolution imaging of hair-cell stereocilia of the inner ear has contributed substantially to our understanding of auditory and vestibular function. To provide three-dimensional views of the structure of stereocilia cytoskeleton and membranes, we developed a… read more here.
Keywords: hair cell; cell stereocilia; cryo tomography; electron cryo ... See more keywords
Direct reprogramming adult fibroblast into cells with partial inner ear hair cell characteristics through cell activation and signal directed approach
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135010
Abstract: Loss of inner ear hair cell (HC) is an irreversible process in mammals and is the most common cause of human hearing and balance disorders especially in the elderly. Cell therapy based on highly scalable… read more here.
Keywords: inner ear; hair cell; cell activation; adult fibroblast ... See more keywords