Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300402
Abstract: The peroxisome is a ubiquitous organelle in rodent cells and plays important roles in a variety of cell types and tissues. It is previously indicated that peroxisomes are associated with auditory function, and patients with… read more here.
Keywords: peroxisome deficiency; atoh1 pex5; cochlear hair; hair cells ... See more keywords
A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4093
Abstract: Aminoglycoside antibiotics are widely used for many life‐threatening infections. The use of aminoglycosides is often comprised by their deleterious side effects to the kidney and inner ear. A novel semisynthetic antibiotic, etimicin, has good antimicrobial… read more here.
Keywords: etimicin; hair cells; zebrafish embryos; ototoxicity ... See more keywords
Protective mechanism of ferulic acid against neomycin‐induced ototoxicity in zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23707
Abstract: Ototoxicity refers to damage of sensory hair cells and functional hearing impairment following aminoglycosides exposure. Previously, we have determined that ferulic acid (FA) protected hair cells against serial concentrations of neomycin‐induced ototoxic damage. The aim… read more here.
Keywords: transgenic zebrafish; hair cells; mechanism; ferulic acid ... See more keywords
Numerical simulation based on three-dimensional model of inner stereocilia
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DOI: 10.1007/s10483-017-2211-6
Abstract: A three-dimensional inner stereocilium model is established by PATRAN. According to the relevant data, the corresponding pressure is applied to one side of the inner stereocilia. The top displacement of the inner stereocilia along the… read more here.
Keywords: three dimensional; stereocilium; hair cells; inner stereocilia ... See more keywords
Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0857-z
Abstract: The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the… read more here.
Keywords: hair cells; hair; mice; spiral ganglion ... See more keywords
Optimized Tuning of Auditory Inner Hair Cells to Encode Complex Sound through Synergistic Activity of Six Independent K+ Current Entities.
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DOI: 10.1016/j.celrep.2020.107869
Abstract: Auditory inner hair cells (IHCs) convert sound vibrations into receptor potentials that drive synaptic transmission. For the precise encoding of sound qualities, receptor potentials are shaped by K+ conductances tuning the properties of the IHC… read more here.
Keywords: hair cells; encode complex; sound; current entities ... See more keywords
A non-toxic dose of cobalt chloride blocks hair cells of the zebrafish lateral line
Sign Up to like & getrecommendations! Published in 2017 at "Hearing Research"
DOI: 10.1016/j.heares.2017.04.001
Abstract: Abstract Experiments on the flow‐sensitive lateral line system of fishes have provided important insights into the function and sensory transduction of vertebrate hair cells. A common experimental approach has been to pharmacologically block lateral line… read more here.
Keywords: lateral line; hair cells; cobalt chloride;
Two cell populations participate in clearance of damaged hair cells from the sensory epithelia of the inner ear
Sign Up to like & getrecommendations! Published in 2017 at "Hearing Research"
DOI: 10.1016/j.heares.2017.04.006
Abstract: The cochlea and the vestibular organs are populated by resident macrophages, but their role in inner ear maintenance and pathology is not entirely clear. Resident macrophages in other organs are responsible for phagocytosis of injured… read more here.
Keywords: inner ear; hair cells; hair; damaged hair ... See more keywords
Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Hearing Research"
DOI: 10.1016/j.heares.2020.108019
Abstract: Abstract Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is… read more here.
Keywords: lateral line; hair cells; hair; zebrafish lateral ... See more keywords
Memory for sound: The BEAMS Hypothesis [Perspective]
Sign Up to like & getrecommendations! Published in 2021 at "Hearing Research"
DOI: 10.1016/j.heares.2021.108291
Abstract: h 0 For a musician, keen tuning to the pitch and timbre of one’s nstrument is important. For a bilingual, the distinctive pitch, phoetic repertoire, and cadence of one’s two languages are imporant. For an… read more here.
Keywords: hair cells; beams hypothesis; sound beams; brain ... See more keywords
ATP depletion induced cochlear hair cells death through histone deacetylation in vitro
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DOI: 10.1016/j.neulet.2020.134918
Abstract: Previous studies have shown histone modifications being present in cochlear hair cells in animal models of hearing loss. Our past studies have shown that ATP depletion, histone deacetylase (HDAC) upregulation, and histone deacetylation occur in… read more here.
Keywords: hair cells; hair; cochlear hair; histone ... See more keywords