Utility of hairless rats as a model for predicting transdermal pharmacokinetics in humans
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2019.1703059
Abstract: Abstract This study investigated the use of HWY hairless rats to predict human plasma concentrations of drugs following dermal application. Utilizing a deconvolution method, pharmacokinetic parameters (e.g. in vivo absorption rates) were determined for six… read more here.
Keywords: hair follicle; hairless rats; hairless; hydrophilic compounds ... See more keywords
Acclimation of Hairless Spontaneously Hypertensive Rat to Ambient Temperature Attenuates Hypertension-Induced Pro-Arrhythmic Downregulation of Cx43 in the Left Heart Ventricle of Males
Sign Up to like & getrecommendations! Published in 2024 at "Biomolecules"
DOI: 10.3390/biom14121509
Abstract: Objectives: Due to poor treatment adherence and lifestyle-based interventions, chronic hypertension is a dominant risk factor predisposing individuals to heart failure and malignant arrhythmias. We investigated the impact of the postnatal acclimation of hairless SHR… read more here.
Keywords: heart ventricles; heart; hairless shr; ventricle ... See more keywords
Protective Effect of Octylmethoxycinnamate against UV-Induced Photoaging in Hairless Mouse via the Regulation of Matrix Metalloproteinases
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DOI: 10.3390/ijms19071836
Abstract: Ultraviolet (UV) irradiation damages skin and produces symptoms of photoaging, such as thickening, rough texture, wrinkles, and pigmentation. However, the cellular and molecular mechanisms underlying photoaging induced by chronic UV irradiation are not yet fully… read more here.
Keywords: matrix metalloproteinases; irradiation; protective effect; hairless ... See more keywords
Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
Sign Up to like & getrecommendations! Published in 2019 at "Toxicological Research"
DOI: 10.5487/tr.2019.35.4.353
Abstract: The purpose of this study was to investigate the effect of 7-MEGA™ 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed… read more here.
Keywords: alleviation ultraviolet; induced photoaging; mega 500; skin ... See more keywords