An Engineered β‐Hairpin Peptide Forming Thermostable Complexes with ZnII, NiII, and CuII through a His3 Site
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200588
Abstract: The three‐dimensional structure of a peptide, which determines its function, can denature at elevated temperatures, in the presence of chaotropic reagents, or in organic solvents. These factors limit the applicability of peptides. Herein, we present… read more here.
Keywords: hairpin peptide; spectroscopy; geometry; engineered hairpin ... See more keywords
Stabilized β-Hairpin Peptide Inhibits Insulin Degrading Enzyme.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00418
Abstract: Insulin-degrading enzyme (IDE) plays a critical role in both the proteolytic degradation and inactivation of insulin. The exploration of novel IDE inhibitors could aid in the study of novel therapeutics for type-2 diabetes. Herein, we… read more here.
Keywords: peptide; degrading enzyme; insulin degrading; hairpin peptide ... See more keywords
A β-hairpin peptide with pH-controlled affinity for tumor cells.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc06218b
Abstract: Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions.… read more here.
Keywords: tumor; tumor cells; hairpin peptide; controlled affinity ... See more keywords
Charge reversal hairpin peptide modified synergy therapeutic nanoplatforms for tumor specific drug shuttling.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00817c
Abstract: Given the distinct pathological features of neoplasm tissues, multifunctional responsive nanocarriers have been recently considered as promising candidates to optimize the chemotherapy regime. As a result, we propose a graphene oxide-based pH-responsive drug delivery system… read more here.
Keywords: tumor specific; hairpin peptide; charge reversal; graphene oxide ... See more keywords