Stable Hairpin Structures Formed by Xylose‐Based Nucleic Acids
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DOI: 10.1002/cbic.202000803
Abstract: Xenobiology explores synthetic nucleic acid polymers as alternative carriers of genetic information to expand the central dogma. The xylo‐ and deoxyxylo‐nucleic acids (XyNA and dXyNA), containing 3’ epimers of riboses and deoxyriboses, are considered to… read more here.
Keywords: structures formed; stable hairpin; nucleic acids; xylose based ... See more keywords
Small Molecule Modulation of APOBEC3A-Catalyzed Cytosine Deamination in CCG Repeat Deoxyribonucleic Acid via Stabilization of Hairpin Structures.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.5c00501
Abstract: Repeat expansions in the genome are associated with numerous genetic diseases. The instability of repeat sequences is driven in part by slipped-out structures, such as hairpins. APOBEC3A (A3A), a cytosine deaminase, preferentially targets single-stranded DNA,… read more here.
Keywords: repeat; hairpin structures; deamination; ccg ... See more keywords