Protein Engineering Strategies for Improved Pharmacokinetics
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202101633
Abstract: Protein therapeutics have gained momentum in recent years and become a pillar in treating many diseases and the only choice in several ailments. Protein therapeutics are highly specific, tunable, and less toxic than conventional small… read more here.
Keywords: engineering strategies; engineering; half life; strategies improved ... See more keywords
Engineered FcRn Binding Fusion Peptides Significantly Enhance the Half-Life of a Fab Domain in Cynomolgus Monkeys.
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology journal"
DOI: 10.1002/biot.201800007
Abstract: There is a rapidly growing reinvigoration of the investigation of small proteins, cyclic peptides, and mAb derived domains as biotherapies. The drugability of these structures are challenged by fast peripheral clearance properties that can reduce… read more here.
Keywords: fcrn binding; cynomolgus monkeys; fab; fusion ... See more keywords
Development of a mono-specific anti-VEGF bivalent nanobody with extended plasma half-life for treatment of pathologic neovascularization.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2693
Abstract: Vascular Endothelial Growth Factor (VEGF) plays a crucial role in angiogenesis within solid cancers. Thus, targeting VEGF might be part of a feasible therapy for treating pathological neovascularization, and nanobodies - derived from Heavy chain-only… read more here.
Keywords: bivalent nanobody; nanobody; half life; vegf ... See more keywords
Building a Conceptual Model for the Environmental Fate of the Fungicide Benzovindiflupyr
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5603
Abstract: Degradation of the fungicide benzovindiflupyr was slow in standard regulatory laboratory studies in soil and aquatic systems, suggesting it is a persistent molecule. However, the conditions in these studies differed significantly from actual environmental conditions,… read more here.
Keywords: fungicide benzovindiflupyr; half life; life; environmental fate ... See more keywords
Biodegradable Nanoagents with Short Biological Half-Life for SPECT/PAI/MRI Multimodality Imaging and PTT Therapy of Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201702700
Abstract: Rapid clearance of nanoagents is a critical criterion for their clinical translation. Herein, it is reported that biodegradable and renal clearable nanoparticles are potentially useful for image-guided photothermal therapy of tumors. The multifunctional nanoparticles with… read more here.
Keywords: biological half; therapy tumors; short biological; therapy ... See more keywords
What are mechanisms of re-sedation caused by remimazolam?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Anesthesia"
DOI: 10.1007/s00540-021-02926-8
Abstract: I read with great interest the article “Re‐sleeping after rever‐ sal of remimazolam by flumazenil” by Yamamoto et al. [1]. I think that this report is important, because rare phenomena only appear after a large… read more here.
Keywords: sedation; drug; mechanisms sedation; sedation caused ... See more keywords
Structural basis of serum albumin recognition by SL335, an antibody Fab extending the serum half-life of protein therapeutics.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.133
Abstract: Human serum albumin (HSA) has been used to extend the serum half-lives of various protein therapeutics through genetic fusion because HSA exhibits an exceptionally long circulation time as a result of neonatal Fc receptor (FcRn)-mediated… read more here.
Keywords: hsa; serum half; serum; sl335 ... See more keywords
A single injection of CM1021, a long half-life hepatocyte growth factor mimetic, increases liver mass in mice
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101186
Abstract: Despite years of positive animal data, hepatocyte growth factor (HGF) has never been developed into a useful pharmaceutical, primarily due to its poor pharmacological properties. CM1021 is a fusion protein containing the K1 loop of… read more here.
Keywords: half life; growth; hepatocyte growth; growth factor ... See more keywords
Boosting half-life and effector functions of therapeutic antibodies by Fc-engineering: An interaction-function review.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.07.141
Abstract: Due mainly to their high level of affinity and specificity, therapeutic monoclonal antibodies (mAbs) have been frequently selected as treatment for cancer, autoimmune or chronic inflammatory diseases. Despite the increasing number of mAbs and related… read more here.
Keywords: life effector; engineering; half life; antibody ... See more keywords
Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.103746
Abstract: Summary Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable pharmacokinetics, it is crucial to identify the… read more here.
Keywords: half life; plasma half; transport; variable sequences ... See more keywords
Benzodiazepine Dispensing to Persons With Dementia in France, 2011-2016: A Nationwide Study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Medical Directors Association"
DOI: 10.1016/j.jamda.2020.02.019
Abstract: OBJECTIVE To study temporal trends of benzodiazepine exposure among incident Alzheimer's disease and related dementia (ADRD) cohorts between 2011 and 2016. DESIGN Repeated cross-sectional study. SETTING AND PARTICIPANTS Three nationwide incident ADRD cohorts (community-dwelling and institutionalized… read more here.
Keywords: benzodiazepine; exposure; study; prescription ... See more keywords