dGMP Binding to Thymidylate Kinase from Plasmodium falciparum Shows Half-Site Binding and Induces Protein Dynamics at the Dimer Interface.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00898
Abstract: Plasmodium falciparum thymidylate kinase (PfTMK) is an essential enzyme for the growth of the organism because of its critical role in the de novo synthesis of deoxythymidine 5'-diphosphate (TDP), a precursor for TTP that is… read more here.
Keywords: dgmp binding; dgmp; plasmodium falciparum; half site ... See more keywords
Zinc cluster transcription factors frequently activate target genes using a non-canonical half-site binding mode.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad320
Abstract: Abstract Gene expression changes are orchestrated by transcription factors (TFs), which bind to DNA to regulate gene expression. It remains surprisingly difficult to predict basic features of the transcriptional process, including in vivo TF occupancy.… read more here.
Keywords: zinc; zinc cluster; half site; transcription factors ... See more keywords
Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1198
Abstract: Cooperative binding of transcription factors is known to be important in the regulation of gene expression programs conferring cellular identities. However, current methods to measure cooperativity parameters have been laborious and therefore limited to studying… read more here.
Keywords: quantitative profiling; coop seq; half site; sox pou ... See more keywords