Single molecule studies reveal that p53 tetramers dynamically bind response elements containing one or two half sites
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DOI: 10.1038/s41598-020-73234-6
Abstract: The tumor suppressor protein p53 is critical for cell fate decisions, including apoptosis, senescence, and cell cycle arrest. p53 is a tetrameric transcription factor that binds DNA response elements to regulate transcription of target genes.… read more here.
Keywords: dna; p53 tetramers; half sites; p53 ... See more keywords
An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad278
Abstract: Abstract Tryptophanyl-tRNA synthetase (TrpRS) links tryptophan to tRNATrp, thereby playing an indispensable role in protein translation. Unlike most class I aminoacyl-tRNA synthetases (AARSs), TrpRS functions as a homodimer. Herein, we captured an ‘open-closed’ asymmetric structure… read more here.
Keywords: asymmetric structure; half sites; catalytic mechanism; trprs ... See more keywords