Zinc-mediated carboxylations of allylic and propargylic halides in flow: synthesis of β-lactones via subsequent bromolactonization
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DOI: 10.1039/d2ra07715a
Abstract: Zinc-mediated carboxylation of allylic halides under flow conditions delivered β,γ-unsaturated carboxylic acids and subsequent bromolactonization provides a streamlined process for the synthesis of γ-bromo-β-lactones. The described process further demonstrates the utility of organozinc reagents prepared… read more here.
Keywords: halides flow; zinc mediated; subsequent bromolactonization; synthesis ... See more keywords