Telomeres: history, health, and hallmarks of aging
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2020.12.028
Abstract: The escalating social and economic burden of an aging world population has placed aging research at center stage. The hallmarks of aging comprise diverse molecular mechanisms and cellular systems that are interrelated and act in… read more here.
Keywords: history health; health hallmarks; hallmarks aging; telomeres history ... See more keywords
Benefits of Metformin in Attenuating the Hallmarks of Aging.
Sign Up to like & getrecommendations! Published in 2020 at "Cell metabolism"
DOI: 10.1016/j.cmet.2020.04.001
Abstract: Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related disorders and improves health span, is the first drug to be tested… read more here.
Keywords: attenuating hallmarks; metformin attenuating; hallmarks aging; benefits metformin ... See more keywords
From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs
Sign Up to like & getrecommendations! Published in 2019 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201809854
Abstract: Reversing or slowing the aging process brings great promise to treat or prevent age‐related disease, and targeting the hallmarks of aging is a strategy to achieve this. Epigenetics affects several if not all of the… read more here.
Keywords: molecular promise; healthy aging; promise preclinical; hdac inhibitors ... See more keywords
Macrophage multinucleated giant cells: hallmarks of the aging ovary.
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction"
DOI: 10.1530/rep-20-0489
Abstract: Inflammaging is a state of chronic, low grade inflammation associated with biological aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by… read more here.
Keywords: hallmarks aging; cells hallmarks; giant cells; macrophage multinucleated ... See more keywords
Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.
Sign Up to like & getrecommendations! Published in 2022 at "Aging"
DOI: 10.18632/aging.203960
Abstract: Aging biology is a promising and burgeoning research area that can yield dual-purpose pathways and protein targets that may impact multiple diseases, while retarding or possibly even reversing age-associated processes. One widely used approach to… read more here.
Keywords: age; hallmarks aging; associated targets; discovery ... See more keywords
Hallmarks of Aging: An Autophagic Perspective
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00790
Abstract: Autophagy is a major protein turnover pathway by which cellular components are delivered into the lysosomes for degradation and recycling. This intracellular process is able to maintain cellular homeostasis under stress conditions, and its dysregulation… read more here.
Keywords: autophagic perspective; aging autophagic; process; hallmarks aging ... See more keywords
Role of mitophagy in the hallmarks of aging
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomedical Research"
DOI: 10.7555/jbr.36.20220045
Abstract: Aging, subjected to scientific scrutiny, is extensively defined as a time-dependent decline in functions that involves the majority of organisms. The time-dependent accretion of cellular lesions is generally a universal trigger of aging, while mitochondrial… read more here.
Keywords: role mitophagy; hallmarks aging; mitophagy hallmarks;