PBX1: a key character of the hallmarks of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02139-2
Abstract: Pre-B-cell leukemia homeobox transcription factor 1 (PBX1) was first identified as part of a fusion protein resulting from the chromosomal translocation t(1;19) in pre-B cell acute lymphoblastic leukemias. Since then, PBX1 has been associated with… read more here.
Keywords: transcription; pbx1; cancer pbx1; cancer ... See more keywords
Targeting hallmarks of cancer with a food-system-based approach.
Sign Up to like & getrecommendations! Published in 2019 at "Nutrition"
DOI: 10.1016/j.nut.2019.110563
Abstract: Although extensive resources are dedicated to the development and study of cancer drugs, the cancer burden is expected to rise by about 70% over the next 2 decade. This highlights a critical need to develop… read more here.
Keywords: food system; food; cancer; hallmarks cancer ... See more keywords
A systematic review and meta-analysis of prognostic biomarkers in resectable esophageal adenocarcinomas
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31548-6
Abstract: Targeted therapy is lagging behind in esophageal adenocarcinoma (EAC). To guide the development of new treatment strategies, we provide an overview of the prognostic biomarkers in resectable EAC treated with curative intent. The Medline, Cochrane… read more here.
Keywords: biomarkers resectable; systematic review; prognostic biomarkers; meta ... See more keywords
The role of B-Cell Lymphoma-3 (BCL-3) in enabling the hallmarks of cancer: implications for the treatment of colorectal carcinogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaa003
Abstract: Abstract With its identification as a proto-oncogene in chronic lymphocytic leukaemia and central role in regulating NF-κB signalling, it is perhaps not surprising that there have been an increasing number of studies in recent years… read more here.
Keywords: enabling hallmarks; role; cancer; bcl ... See more keywords
Hallmarks of cancer—the new testament
Sign Up to like & getrecommendations! Published in 2021 at "Open Biology"
DOI: 10.1098/rsob.200358
Abstract: Diagnosis and treatment of disease demand a sound understanding of the underlying mechanisms, determining any Achilles' heel that can be targeted in effective therapies. Throughout history, this endeavour to decipher the origin and mechanism of… read more here.
Keywords: cancer new; disease; biology; cancer ... See more keywords
Pan‐cancer RNA‐seq data stratifies tumours by some hallmarks of cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14746
Abstract: Numerous genetic and epigenetic alterations cause functional changes in cell biology underlying cancer. These hallmark functional changes constitute potentially tissue‐independent anticancer therapeutic targets. We hypothesized that RNA‐Seq identifies gene expression changes that underly those hallmarks,… read more here.
Keywords: pan cancer; stratifies tumours; gene expression; cancer ... See more keywords
Hallmarks of Cancer: New Dimensions.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-21-1059
Abstract: The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets… read more here.
Keywords: new dimensions; biology; pathology; cancer ... See more keywords
Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations
Sign Up to like & getrecommendations! Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-04105-8
Abstract: Background The hallmarks of cancer provide a highly cited and well-used conceptual framework for describing the processes involved in cancer cell development and tumourigenesis. However, methods for translating these high-level concepts into data-level associations between… read more here.
Keywords: ontology; consensus; based gene; cancer ... See more keywords
Heparanase and the hallmarks of cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-020-02624-1
Abstract: Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to heparan… read more here.
Keywords: heparanase; within tumour; cancer; tumour microenvironment ... See more keywords
A pro-oxidant combination of resveratrol and copper down-regulates hallmarks of cancer and immune checkpoints in patients with advanced oral cancer: Results of an exploratory study (RESCU 004)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1000957
Abstract: Background Our earlier studies have shown that cell-free chromatin particles (cfChPs) that are released from dying cancer cells are readily internalised by bystander cells leading to activation of two hallmarks of cancer viz. genome instability… read more here.
Keywords: cfchps; cancer cells; microscopy; immune checkpoints ... See more keywords
Hallmarks of cancer: The insulin-like growth factors perspective
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1055589
Abstract: The identification of a series of attributes or hallmarks that are shared by virtually all cancer cells constitutes a true milestone in cancer research. The conceptualization of a catalogue of common genetic, molecular, biochemical and… read more here.
Keywords: oncology; insulin like; like growth; cancer ... See more keywords