Synthesis of Spirocyclic Isoindolones Using an Alkynyl aza-Prins/Oxidative halo-Nazarov Cyclization Sequence.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00191
Abstract: In this report, we describe an alkynyl halo-aza-Prins cyclization of 3-hydroxyisoindolones to prepare aza-Prins products. These Prins adducts undergo oxidation at the 3-isoindolone position after activation of the amide by triflic anhydride and 2-chloropyridine to… read more here.
Keywords: nazarov cyclization; aza prins; halo nazarov; halo ... See more keywords
Nitrogen-interrupted halo-Prins/halo-Nazarov fragment coupling cascade for the synthesis of indolines
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00986f
Abstract: The nitrogen-interrupted Nazarov cyclization can be a powerful method for the stereocontrolled synthesis of sp3-rich N-heterocycles. However, due to the incompatibility between the basicity of nitrogen and the acidic reaction conditions, examples of this type… read more here.
Keywords: halo prins; prins halo; halo nazarov; interrupted halo ... See more keywords