An asymmetric synthesis of febrifugine, halofuginone and their hemiketal isomers
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DOI: 10.1016/j.tet.2017.07.041
Abstract: Abstract A new synthesis of both enantiomers of naturally occurring febrifugine ( 1 ) and its analogue halofuginone ( 3 ) are reported. This robust route relies on an enzymatic kinetic resolution (EKR)-cross metathesis (CM)… read more here.
Keywords: synthesis febrifugine; febrifugine halofuginone; halofuginone hemiketal; halofuginone ... See more keywords
Anti-Phytophthora Activity of Halofuginone and the Corresponding Mode of Action.
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DOI: 10.1021/acs.jafc.2c04266
Abstract: Febrifugine, a natural alkaloid, exhibits specific anti-phytophthora activity; however, its mode of action is unclear. In this study, halofuginone, a synthetic derivative of febrifugine, showed significantly higher anti-phytophthora activities than those of febrifugine and the… read more here.
Keywords: anti phytophthora; mode action; phytophthora activity; halofuginone ... See more keywords
Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase.
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DOI: 10.1021/acs.jmedchem.2c01496
Abstract: Aminoacyl-tRNA synthetases (aaRSs) are promising antimicrobial targets due to their essential roles in protein translation, and expanding their inhibitory mechanisms will provide new opportunities for drug discovery. We report here that halofuginone (HF), an herb-derived… read more here.
Keywords: structure; guided design; prolyl trna; atp aided ... See more keywords
Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.
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DOI: 10.14670/hh-18-083
Abstract: In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring… read more here.
Keywords: hydroxy group; muscle; fibrosis; histopathology ... See more keywords