Halogen Substituents in the Isoquinoline Scaffold Switches the Selectivity of Inhibition between USP2 and USP7
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DOI: 10.1002/cbic.201800612
Abstract: Deubiquitinases are important components of the protein regulatory network and, hence, constitute a tempting drug target. We report herein structure–activity relationship studies to develop halogen‐substituted isoquionoline‐1,3‐dione‐based inhibitors of the deubiquitinase USP2. In contrast to our… read more here.
Keywords: switches selectivity; inhibition; halogen substituents; halogen ... See more keywords
The effects of halogen substituents on the catalytic oxidation of benzyl-alcohols in the presence of dinuclear oxidovanadium(IV) complex
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.05.049
Abstract: Abstract A new dinuclear complex of oxidovanadium(IV), namely [(VO)2(HL)(μ-O)] (1), has been synthesized by the reaction of VO(acac)2 with the heptadentate N4O3-donor Schiff base ligand, 2-(5-Bromo-2-hydroxyphenyl)-1,3-bis(2-(5-bromo-2-hydroxybenzylideneamino)ethyl)imidazolidine (H3L). The complex has been characterized by elemental analysis,… read more here.
Keywords: benzyl; effects halogen; halogen substituents; benzyl alcohols ... See more keywords
Halogenated isophthalamides and dipicolineamides: the role of the halogen substituents in the anion binding properties.
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DOI: 10.1039/d0dt01492c
Abstract: A novel family of amide-based receptors is herein described. Specifically, the role of the halogen substituents at the aryl moieties in the anion binding properties of a series of halogenated isophthalamides and dipicolineamides (L1-L6) was… read more here.
Keywords: halogenated isophthalamides; role halogen; halogen substituents; halogen ... See more keywords
Fast relaxing red and near-IR switchable azobenzenes with chalcogen and halogen substituents: periodic trends, tuneable thermal half-lives and chalcogen bonding
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DOI: 10.1039/d2sc04601f
Abstract: Molecular photoswitches operating in the red to near-IR region with controllable thermal relaxation rates are attractive components for photo-regulating biological processes. Herein, we report the synthesis of red-shifted azobenzenes functionalised with the heavier chalcogens and… read more here.
Keywords: periodic trends; chalcogen halogen; red near; chalcogen bonding ... See more keywords