Halogenase-Assisted Alkyne/Aryl Bromide Sonogashira Coupling for Ribosomally Synthesized Peptides
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DOI: 10.1021/jacs.4c12210
Abstract: We describe the enzymatic bromination of ribosomally synthesized peptides and develop protocols for Sonogashira coupling of peptidic aryl bromides with a panel of alkynes. Using this workflow, entirely new chemical handles are introduced onto ribosomal… read more here.
Keywords: chemistry; aryl bromide; halogenase assisted; ribosomally synthesized ... See more keywords