Development of Halogenase Enzymes for Use in Synthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.7b00032
Abstract: Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of biosynthetic precursors, with the halogens introduced often having a profound effect on the biological activity of the resulting natural products. Synthetic endeavors to… read more here.
Keywords: development halogenase; halogenase enzymes; enzymes use; halogenase ... See more keywords
Halogenation of Peptides and Proteins Using Engineered Tryptophan Halogenase Enzymes
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121841
Abstract: Halogenation of bioactive peptides via incorporation of non-natural amino acid derivatives during chemical synthesis is a common strategy to enhance functionality. Bacterial tyrptophan halogenases efficiently catalyze regiospecific halogenation of the free amino acid tryptophan, both… read more here.
Keywords: halogenase enzymes; halogenation; halogenase; proteins using ... See more keywords