Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-b]pyridinol Derivatives as Potent Topoisomerase IIα-targeted Chemotherapeutic Agents for Breast Cancer.
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DOI: 10.1021/acs.jmedchem.9b00970
Abstract: With the aim of developing new effective topoisomerase IIα-targeted anticancer agents, we synthesized a series of hydroxy- and halogenated 2,4-diphenyl indeno[1,2-b]pyridinols using a microwave-assisted single step synthetic method, and investigated structure-activity relationships. The majority of… read more here.
Keywords: topoisomerase targeted; halogenated diphenyl; breast cancer; topoisomerase ... See more keywords