Three-Component Cyclization/Haloazidation of Bicyclo[1.1.0]butane-1-carboxamides: Construction of Halogenated Spiro[cyclobutane-1,3'-quinolin]-2'-one Derivatives.
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DOI: 10.1021/acs.orglett.5c03545
Abstract: A new BCB-type substrate to assemble halogenated spiro[cyclobutane-1,3'-quinolin]-2'-one derivatives via a radical cascade strain-release cyclization reaction has been successfully developed. The reaction features broad substrate scope, mild reaction conditions, and separated diastereomers. Importantly, the reaction… read more here.
Keywords: spiro cyclobutane; halogenated spiro; cyclobutane quinolin; one derivatives ... See more keywords