Enzymatic Late‐Stage Halogenation of Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200569
Abstract: The late‐stage site‐selective derivatisation of peptides has many potential applications in structure‐activity relationship studies and postsynthetic modification or conjugation of bioactive compounds. The development of orthogonal methods for C−H functionalisation is crucial for such peptide… read more here.
Keywords: stage halogenation; enzymatic late; halogenation; halogenation peptides ... See more keywords
Perfect Partners: Biocatalytic Halogenation and Metal Catalysis for Protein Bioconjugation
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400496
Abstract: Flavin‐dependent halogenases (FDHs) are the most extensively researched halogenases and show great potential for biotransformation applications. These enzymes use chloride, bromide, or iodide ions as halogen donors to catalyze the oxygen‐dependent halogenation of electron‐rich aryl… read more here.
Keywords: cross coupling; biocatalytic halogenation; halogenation; protein ... See more keywords
Chemoenzymatic Synthesis of 3‐Halochromones via Oxidative α‐Halogenation of Enaminones in TPGS‐750‐M Micelles
Sign Up to like & getrecommendations! Published in 2025 at "ChemBioChem"
DOI: 10.1002/cbic.202500277
Abstract: Synthesis strategies of chromones have been widely investigated due to the abundance of chromone moiety in bioactive compounds and natural products. Of which, 3‐halochromones are a versatile set of precursors to synthetically access valuable compounds… read more here.
Keywords: tpgs 750; halogenation; oxidative halogenation; chemoenzymatic synthesis ... See more keywords
Re‐Programming and Optimization of a L‐Proline cis‐4‐Hydroxylase for the cis‐3‐Halogenation of its Native Substrate
Sign Up to like & getrecommendations! Published in 2021 at "ChemCatChem"
DOI: 10.1002/cctc.202100591
Abstract: Non‐heme iron/α‐ketoglutarate dependent halogenases acting on freestanding substrates catalyze the regio‐ and stereoselective halogenation of inactivated C(sp3)‐H bonds. Yet, with only a handful of these halogenases characterized, the biosynthetic potential of enzymatic radical halogenation remains… read more here.
Keywords: cis; proline cis; halogenation; cis hydroxylase ... See more keywords
Organocatalytic Halogenation of Aromatic and Heteroaromatic Compounds
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500125
Abstract: The halogenation of aromatic and heteroaromatic systems has attracted considerable attention in recent decades owing to the importance of haloaromatics in biologically relevant compounds and their role as essential building blocks for more complex systems.… read more here.
Keywords: chemistry; organocatalytic halogenation; halogenation; heteroaromatic compounds ... See more keywords
Peptide halogenation biochemistry: interfacing pharmaceutical deliverables with chemical innovation
Sign Up to like & getrecommendations! Published in 2025 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-025-03488-0
Abstract: The biosynthetic schemes for the production of halogenated peptidic natural products offer avenues for the discovery of peptide halogenases, and opportunities for development of biocatalysts for derivatization of peptides and proteins. Here, a short review… read more here.
Keywords: biochemistry interfacing; peptide halogenation; halogenation; interfacing pharmaceutical ... See more keywords
Engineering cellulose nanopaper with water resistant, antibacterial, and improved barrier properties by impregnation of chitosan and the followed halogenation.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.118372
Abstract: This work demonstrated a facile and sustainable approach to functionalize cellulose nanopaper (CNP) by impregnation of chitosan (CS) and the followed halogenation. It was found that the tensile strength of the functionalized CNP (CNP/CS-Cl) was… read more here.
Keywords: cnp; cellulose nanopaper; barrier properties; impregnation chitosan ... See more keywords
More Than Just Acetates: PhI(OAc)2 Enables C–H Halogenation of Arenes
Sign Up to like & getrecommendations! Published in 2019 at "Chem"
DOI: 10.1016/j.chempr.2019.01.009
Abstract: In this issue of Chem, Nagib and co-workers report an operationally simple approach for direct C–H halogenation of arenes and (hetero)arenes through in situ activation of commercially available PhI(OAc)2. The resulting non-symmetrical iodanes offer chemists new… read more here.
Keywords: halogenation; enables halogenation; oac enables; acetates phi ... See more keywords
Halogenation of 1,1-diarylethylenes by N-halosuccinimides
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.11.018
Abstract: Abstract An efficient method for the preparation of 2,2-diarylvinyl halides from the corresponding 1,1-diarylethylenes has been developed. N-Halosuccinimides (N-bromosuccinimide or N-chlorosuccinimide) were used as the halogenation reagents. The practicability of this method is highlighted by… read more here.
Keywords: halogenation diarylethylenes; diarylethylenes halosuccinimides; halogenation;
Facile in Situ Halogen Functionalization via Triple-Bond Hydrohalogenation: Enhancing Sorption Capacities through Halogenation to Halofumarate-Based Zr(IV)-Metal-Organic Frameworks
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.9b00524
Abstract: Surface halogenation is an important means to tune or improve functionalities of solid-state materials. However, this concept has been hardly explored and exploited in the engineering of metal-orga... read more here.
Keywords: situ halogen; halogen functionalization; metal; functionalization via ... See more keywords
Production of Polyhalogenated Carbazoles in Marine Red Alga Corallina officinalis: A Possible Natural Source.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.3c00311
Abstract: Polyhalogenated carbazoles (PHCZs) have been increasingly detected in the environment as a result of anthropogenic and natural origin. However, it is unclear how PHCZs are naturally produced. In this study, the formation of PHCZs from… read more here.
Keywords: marine red; bpo catalyzed; phczs; halogenation ... See more keywords