Enzymatic Late‐Stage Halogenation of Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200569
Abstract: The late‐stage site‐selective derivatisation of peptides has many potential applications in structure‐activity relationship studies and postsynthetic modification or conjugation of bioactive compounds. The development of orthogonal methods for C−H functionalisation is crucial for such peptide… read more here.
Keywords: stage halogenation; enzymatic late; halogenation; halogenation peptides ... See more keywords
Re‐Programming and Optimization of a L‐Proline cis‐4‐Hydroxylase for the cis‐3‐Halogenation of its Native Substrate
Sign Up to like & getrecommendations! Published in 2021 at "ChemCatChem"
DOI: 10.1002/cctc.202100591
Abstract: Non‐heme iron/α‐ketoglutarate dependent halogenases acting on freestanding substrates catalyze the regio‐ and stereoselective halogenation of inactivated C(sp3)‐H bonds. Yet, with only a handful of these halogenases characterized, the biosynthetic potential of enzymatic radical halogenation remains… read more here.
Keywords: cis; proline cis; halogenation; cis hydroxylase ... See more keywords
Engineering cellulose nanopaper with water resistant, antibacterial, and improved barrier properties by impregnation of chitosan and the followed halogenation.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.118372
Abstract: This work demonstrated a facile and sustainable approach to functionalize cellulose nanopaper (CNP) by impregnation of chitosan (CS) and the followed halogenation. It was found that the tensile strength of the functionalized CNP (CNP/CS-Cl) was… read more here.
Keywords: cnp; cellulose nanopaper; barrier properties; impregnation chitosan ... See more keywords
More Than Just Acetates: PhI(OAc)2 Enables C–H Halogenation of Arenes
Sign Up to like & getrecommendations! Published in 2019 at "Chem"
DOI: 10.1016/j.chempr.2019.01.009
Abstract: In this issue of Chem, Nagib and co-workers report an operationally simple approach for direct C–H halogenation of arenes and (hetero)arenes through in situ activation of commercially available PhI(OAc)2. The resulting non-symmetrical iodanes offer chemists new… read more here.
Keywords: halogenation; enables halogenation; oac enables; acetates phi ... See more keywords
Halogenation of 1,1-diarylethylenes by N-halosuccinimides
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.11.018
Abstract: Abstract An efficient method for the preparation of 2,2-diarylvinyl halides from the corresponding 1,1-diarylethylenes has been developed. N-Halosuccinimides (N-bromosuccinimide or N-chlorosuccinimide) were used as the halogenation reagents. The practicability of this method is highlighted by… read more here.
Keywords: halogenation diarylethylenes; diarylethylenes halosuccinimides; halogenation;
Facile in Situ Halogen Functionalization via Triple-Bond Hydrohalogenation: Enhancing Sorption Capacities through Halogenation to Halofumarate-Based Zr(IV)-Metal-Organic Frameworks
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.9b00524
Abstract: Surface halogenation is an important means to tune or improve functionalities of solid-state materials. However, this concept has been hardly explored and exploited in the engineering of metal-orga... read more here.
Keywords: situ halogen; halogen functionalization; metal; functionalization via ... See more keywords
Production of Polyhalogenated Carbazoles in Marine Red Alga Corallina officinalis: A Possible Natural Source.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.3c00311
Abstract: Polyhalogenated carbazoles (PHCZs) have been increasingly detected in the environment as a result of anthropogenic and natural origin. However, it is unclear how PHCZs are naturally produced. In this study, the formation of PHCZs from… read more here.
Keywords: marine red; bpo catalyzed; phczs; halogenation ... See more keywords
Directed Structural Transformations of Coordination Polymers Supported Single-Site Cu(II) Catalysts To Control the Site Selectivity of C-H Halogenation.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b01891
Abstract: A main difficulty in C-H bond functionalization is to undertake the catalyst control accurately where the reaction takes place. In this work, to achieve highly effective and regioselective single-site catalysts, a three-dimensional (3D) rhombus-like framework… read more here.
Keywords: single site; selectivity; site; structural transformations ... See more keywords
Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01768
Abstract: The modulation of the A2B adenosine receptor is a promising strategy in cancer (immuno) therapy, with A2BAR antagonists emerging as immune checkpoint inhibitors. Herein, we report a systematic assessment of the impact of (di- and… read more here.
Keywords: affinity; halogenation; a2bar; a2b adenosine ... See more keywords
Effect of Halogenation on the Energetics of Pure and Mixed Phases in Model Organic Semiconductors Composed of Anthradithiophene Derivatives and C60
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Physical Chemistry C"
DOI: 10.1021/acs.jpcc.7b11729
Abstract: Halogenation, particularly fluorination, is commonly used to manipulate the energetics, stability, and morphology of organic semiconductors. In the case of organic photovoltaics (OPVs), fluorination of electron donor molecules or polymers at appropriate positions can lead… read more here.
Keywords: halogenation energetics; adt c60; effect halogenation; energetics pure ... See more keywords
What Drives Radical Halogenation versus Hydroxylation in Mononuclear Nonheme Iron Complexes? A Combined Experimental and Computational Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c01375
Abstract: Nonheme iron halogenases are unique enzymes in nature that selectively activate an aliphatic C–H bond of a substrate to convert it into C–X (X = Cl/Br, but not F/I). It is proposed that they generate… read more here.
Keywords: secondary carbon; transfer; iron; halogenation ... See more keywords