Directed Evolution of Flavin-Dependent Halogenases for Site- and Atroposelective Halogenation of 3-Aryl-4(3H)-Quinazolinones via Kinetic or Dynamic Kinetic Resolution.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07422
Abstract: In this study, we engineer a variant of the flavin-dependent halogenase RebH that catalyzes site- and atroposelective halogenation of 3-aryl-4(3H)-quinazolinones via kinetic or dynamic kinetic resolution. The required directed evolution uses a combination of random… read more here.
Keywords: flavin dependent; atroposelective halogenation; halogenation aryl; site atroposelective ... See more keywords
Dehydroxyalkylative halogenation of C(aryl)-C bonds of aryl alcohols.
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DOI: 10.1039/d0cc02306j
Abstract: We herein report Cu mediated side-directed dehydroxyalkylative halogenation of aryl alcohols. C(aryl)-C bonds of aryl alcohols were effectively cleaved, affording the corresponding aryl chlorides, bromides and iodides in excellent yields. Aryl alcohols could serve as… read more here.
Keywords: aryl alcohols; aryl bonds; dehydroxyalkylative halogenation; bonds aryl ... See more keywords