Enzymatic Late‐Stage Halogenation of Peptides
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DOI: 10.1002/cbic.202200569
Abstract: The late‐stage site‐selective derivatisation of peptides has many potential applications in structure‐activity relationship studies and postsynthetic modification or conjugation of bioactive compounds. The development of orthogonal methods for C−H functionalisation is crucial for such peptide… read more here.
Keywords: stage halogenation; enzymatic late; halogenation; halogenation peptides ... See more keywords
Halogenation of Peptides and Proteins Using Engineered Tryptophan Halogenase Enzymes
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DOI: 10.3390/biom12121841
Abstract: Halogenation of bioactive peptides via incorporation of non-natural amino acid derivatives during chemical synthesis is a common strategy to enhance functionality. Bacterial tyrptophan halogenases efficiently catalyze regiospecific halogenation of the free amino acid tryptophan, both… read more here.
Keywords: halogenase enzymes; halogenation; halogenase; proteins using ... See more keywords