Significant improvement of the enantioselectivity of a halohydrin dehalogenase for asymmetric epoxide ring opening reactions by protein engineering
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DOI: 10.1007/s00253-020-10356-x
Abstract: Halohydrin dehalogenases (HHDHs) have attracted much attention due to their ability to synthesize enantiomerically enriched epoxides and β-haloalcohols. However, most of the HHDHs exhibit low enantioselectivity. Here, a HHDH from the alphaproteobacteria isolate 46_93_T64 (… read more here.
Keywords: enantioselectivity; protein engineering; significant improvement; halohydrin ... See more keywords