Haloperidol Affects Plasticity of Differentiated NG-108 Cells Through σ1R/IP3R1 Complex
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0524-y
Abstract: Haloperidol is an antipsychotic agent that primarily acts as an antagonist of D2 dopamine receptors. Besides other receptor systems, it targets sigma 1 receptors (σ1Rs) and inositol 1,4,5-trisphosphate receptors (IP3Rs). Aim of this work was… read more here.
Keywords: 108 cells; haloperidol; differentiated 108; calcium ... See more keywords
Mortality Risk Associated with Haloperidol Use Compared with Other Antipsychotics: An 11-Year Population-Based Propensity-Score-Matched Cohort Study
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DOI: 10.1007/s40263-019-00693-5
Abstract: Background Haloperidol remains a frequently prescribed first-generation antipsychotic. However, haloperidol-associated mortality risk by all causes, cardiovascular disease (CVD), and pneumonia compared with other antipsychotics is unknown. Objective This study investigated the mortality risk associated with… read more here.
Keywords: mortality risk; risk associated; compared antipsychotics; mortality ... See more keywords
Evidence that haloperidol impairs learning and motivation scores in a probabilistic task by reducing the reward expectation
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112858
Abstract: Activation of midbrain dopamine neurons in response to positive prediction errors and reward predictive cues is proposed to "energize" reward seeking behaviors and approach responses to places where the reward is expected. In the present… read more here.
Keywords: reward expectation; learning motivation; haloperidol; arm ... See more keywords
Intramuscular midazolam, olanzapine, or haloperidol for the management of acute agitation: A multi-centre, double-blind, randomised clinical trial
Sign Up to like & getrecommendations! Published in 2021 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2021.100751
Abstract: Background The safety and effectiveness of intramuscular olanzapine or haloperidol compared to midazolam as the initial pharmacological treatment for acute agitation in emergency departments (EDs) has not been evaluated. Methods A pragmatic, randomised, double-blind, active-controlled… read more here.
Keywords: olanzapine haloperidol; agitation; sedation; haloperidol ... See more keywords
Analysis of big data shows haloperidol with a decreased level of serum potassium
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.02.379
Abstract: Introduction Haloperidol has been used for the treatment of schizophrenic disorders and other disorders with psychotic symptoms in psychiatric cares. It has been reported that haloperidol can cause QT-prolongation as well as Torsades de Pointes,… read more here.
Keywords: analysis big; potassium; haloperidol; levels serum ... See more keywords
HALOPERIDOL DECANOATE INDUCED PANCYTOPENIA: A CASE REPORT
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Geriatric Psychiatry"
DOI: 10.1016/j.jagp.2020.01.143
Abstract: Introduction Blood dyscrasias can occur secondary to antipsychotic drug use which may be due to direct drug toxicity or immunologic mechanisms causing bone marrow suppression. Antipsychotic use mostly causes neutropenia and less frequently thrombocytopenia. Drug-induced… read more here.
Keywords: haloperidol decanoate; case; haloperidol; blood ... See more keywords
Cyclosomatostatin- and haloperidol-induced catalepsy in Wistar rats: Differential responsiveness to sleep deprivation
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.07.012
Abstract: Total sleep deprivation (SD) has been found to mitigate motor dysfunctions in Parkinson's disease. Apparently, the similar sensitivity of an animal model for parkinsonism would support the model's validity. Recently, we described catalepsy induced in… read more here.
Keywords: wistar rats; haloperidol; induced catalepsy; csst ... See more keywords
Aripiprazole and haloperidol protect neurite lesions via reducing excessive D2R-DISC1 complex formation
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2018.12.007
Abstract: &NA; Dopamine D2 receptor (D2R) hyperactivity causes altered brain development and later produces onset of symptoms mimicking schizophrenia. It is known that D2R interacts with disrupted in schizophrenia 1 (DISC1); however, the effect of D2R‐DISC1… read more here.
Keywords: hyperactivity; haloperidol; neurite lesions; disc1 ... See more keywords
The Effects of Cannabidiol on Behavioural and Oxidative Stress Parameters Induced by Prolonged Haloperidol Administration.
Sign Up to like & getrecommendations! Published in 2022 at "Acta neuropsychiatrica"
DOI: 10.1017/neu.2022.29
Abstract: OBJECTIVES We investigated the influence of oral cannabidiol (CBD) on vacuous chewing movements (VCM) and oxidative stress parameters induced by short- and long-term administration of haloperidol, in a rat model of tardive dyskinesia (TD). METHODS… read more here.
Keywords: administration; haloperidol group; sub chronic; chronic haloperidol ... See more keywords
Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00864
Abstract: Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side-effects (EPS) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D2 receptor (D2R) antagonists, with contrasting… read more here.
Keywords: dopamine receptor; kinetic profiling; haloperidol; structure kinetic ... See more keywords
Haloperidol Prevents Oxytosis/Ferroptosis by Targeting Lysosomal Ferrous Ions in a Manner Independent of Dopamine D2 and Sigma-1 Receptors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00398
Abstract: Haloperidol is a widely used antipsychotic agent that exerts antipsychotic effects through a strong antagonism of dopamine D2 receptors. In addition, haloperidol is classified as a sigma-1 receptor (S1R) antagonist that prevents endogenous oxidative stress… read more here.
Keywords: lysosomal ferrous; ferrous ions; oxytosis ferroptosis; dopamine ... See more keywords