Haloperidol Affects Plasticity of Differentiated NG-108 Cells Through σ1R/IP3R1 Complex
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0524-y
Abstract: Haloperidol is an antipsychotic agent that primarily acts as an antagonist of D2 dopamine receptors. Besides other receptor systems, it targets sigma 1 receptors (σ1Rs) and inositol 1,4,5-trisphosphate receptors (IP3Rs). Aim of this work was… read more here.
Keywords: 108 cells; haloperidol; differentiated 108; calcium ... See more keywords
The ANKK1/DRD2 gene TaqIA polymorphism (rs1800497) is associated with the severity of extrapyramidal side effects of haloperidol treatment in CYP2D6 extensive metabolizers with schizophrenia spectrum disorders
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Personalized Therapy"
DOI: 10.1515/dmpt-2022-0143
Abstract: Abstract Objectives Extrapyramidal symptoms (EPS) are one of the most prominent side effects of haloperidol. Variability of EPS severity may be associated with the genetic factors, affecting both haloperidol pharmacokinetics (e.g., CYP2D6) and pharmacodynamics (e.g.,… read more here.
Keywords: schizophrenia spectrum; spectrum disorders; haloperidol treatment; severity ... See more keywords