Abnormal vitamin D and lipid profile in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-05171-1
Abstract: The HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease of host-HTLV-1 interactions. In many virus-associated diseases and multiple sclerosis, the importance of vitamin-D and lipid profile has been demonstrated, thus similarly, their impacts were… read more here.
Keywords: lipid profile; ham; htlv associated; ham tsp ... See more keywords
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients
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DOI: 10.1007/s12010-017-2406-7
Abstract: HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an aggressive neurological disease. The CD4+CD25+ T cell population plays pivotal roles in the maintenance of immunological tolerance and prevention of such autoimmune diseases. In the current study, proviral… read more here.
Keywords: ham; tsp patients; ham tsp; gitr ... See more keywords
Expression of TSLC1 in patients with HAM/TSP
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DOI: 10.1007/s13365-020-00838-z
Abstract: Human T-lymphotropic virus type 1 (HTLV-1)–associated myelopathy/tropical spastic paraparesis (HAM/TSP) is chronic myelopathy characterized by slowly progressive spastic paraparesis and urinary dysfunction. A few biomarkers in the cerebrospinal fluid are known to be related to… read more here.
Keywords: expression level; tslc1; ham tsp; disease activity ... See more keywords
Cardiovascular risk factors and brain white matter lesions in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurovirology"
DOI: 10.1007/s13365-022-01063-6
Abstract: The origin of brain white matter lesion found in HTLV-1-associated myelopathy (HAM/TSP) remains undefined. We investigated the association between white matter lesions in HAM/TSP with cardiovascular risk factors. The group of 40 patients with HAM/TSP… read more here.
Keywords: cardiovascular risk; brain; white matter; ham tsp ... See more keywords
Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2017.11.010
Abstract: INTRODUCTION Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association… read more here.
Keywords: ham; htlv infected; ham tsp; hla kir ... See more keywords
STLV-1 Commonly Targets Neurons in the Brain of Asymptomatic Non-Human Primates
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DOI: 10.1128/mbio.03526-22
Abstract: The human T-cell leukemia virus (HTLV)-1 is responsible for an aggressive neurodegenerative disease (HAM/TSP) and multiple neurological alterations. The capacity of HTLV-1 to infect central nervous system (CNS) resident cells, together with the neuroimmune-driven response,… read more here.
Keywords: commonly targets; neurons brain; brain; stlv commonly ... See more keywords
Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Sign Up to like & getrecommendations! Published in 2019 at "Retrovirology"
DOI: 10.1186/s12977-019-0499-5
Abstract: Human T cell lymphotropic virus 1 (HTLV-1) is a human retrovirus and infects approximately 10–20 million people worldwide. While the majority of infected people are asymptomatic carriers of HTLV-1, only 4% of infected people develop HTLV-1-associated… read more here.
Keywords: ham; htlv associated; myelopathy tropical; associated myelopathy ... See more keywords
An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis
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DOI: 10.1186/s12977-019-0508-8
Abstract: BackgroundHuman T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the central nervous system that significantly affected spinal cord, nevertheless, the pathogenesis pathway and reliable biomarkers have not been well determined. This… read more here.
Keywords: ham; throughput; analysis; ham tsp ... See more keywords
Clinical course of neurogenic bladder dysfunction in human T-cell leukemia virus type-1-associated myelopathy/tropical spastic paraparesis: a nationwide registry study in Japan
Sign Up to like & getrecommendations! Published in 2021 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-021-01990-3
Abstract: Background Most patients with human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) develop neurogenic bladder dysfunction. However, longitudinal changes and treatment effects remain poorly understood. This study aimed to characterize the clinical course… read more here.
Keywords: ham; bladder dysfunction; dysfunction; ham tsp ... See more keywords
Management of HAM/TSP
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DOI: 10.1212/cpj.0000000000000832
Abstract: Purpose of Review To provide an evidence-based approach to the use of therapies that are prescribed to improve the natural history of HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP)—a rare disease. Recent Findings All 41 articles on… read more here.
Keywords: use; ham tsp; evidence; therapy ... See more keywords
Bladder dysfunction in human T cell lymphotropic virus infection: A prospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009772
Abstract: Background While bladder dysfunction is observed in the majority of patients with human T cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM), it is also observed in patients who do not fulfill all diagnostic criteria… read more here.
Keywords: tsp; bladder dysfunction; ham tsp;