Structural Simplicity and Mechanistic Complexity in the Hammerhead Ribozyme.
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DOI: 10.1016/bs.pmbts.2018.07.006
Abstract: Natural or full-length hammerhead ribozymes are up to 1000-fold more active than their minimal counterparts that lack a complex tertiary interaction that pre-organizes and stabilizes the ribozyme active site, positioning RNA functional groups to facilitate… read more here.
Keywords: hammerhead; hammerhead ribozyme; mechanistic complexity; structural simplicity ... See more keywords