Egr3 as an important regulator of uterine decidualization through targeting Hand2
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11933
Abstract: Early growth response 3 (Egr3) is required for embryogenesis, but little understanding is usable about its function in embryo implantation and decidualization. The present study exhibited an obvious localization of Egr3 in luminal epithelium and… read more here.
Keywords: egr3; regulator uterine; decidualization; hand2 ... See more keywords
Long noncoding RNA HAND2‐AS1 inhibits cancer cell proliferation, migration, and invasion in esophagus squamous cell carcinoma by regulating microRNA‐21
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28233
Abstract: Long noncoding RNA (lncRNA) HAND2‐AS1 is a well‐characterized tumor suppressor in several types of malignancies, while its role in esophagus squamous cell carcinoma (ESCC) is unknown. In this study, we found that lncRNA HAND2‐AS1 was… read more here.
Keywords: cell proliferation; hand2 as1; lncrna hand2; hand2 ... See more keywords
Long-term, induced expression of Hand2 in peripheral sympathetic neurons ameliorates sarcopenia in geriatric mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12790
Abstract: BACKGROUND The discovery of adrenoceptors, which mediate the effects of the sympathetic nervous system neurotransmitter norepinephrine on specific tissues, sparked the development of sympathomimetics that have profound influence on skeletal muscle mass. However, chronic administration… read more here.
Keywords: iix; muscle; muscle mass; expression ... See more keywords
HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05470-y
Abstract: Adipocytes are critical cornerstones of energy metabolism. While obesity-induced adipocyte dysfunction is associated with insulin resistance and systemic metabolic disturbances, adipogenesis, the formation of new adipocytes and healthy adipose tissue expansion are associated with metabolic… read more here.
Keywords: obesity linked; transcription factor; hand2; obesity ... See more keywords
Long non-coding RNA HAND2-AS1 inhibits invasion and metastasis in endometrioid endometrial carcinoma through inactivating neuromedin U.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.10.028
Abstract: Endometrioid endometrial carcinoma (EEC) is one of the common causes of cancer-related mortality in women. Mounting evidences suggest that long noncoding RNAs (lncRNAs) function in multiple cancers. In this study, we discovered that HAND2-AS1, a… read more here.
Keywords: endometrioid endometrial; invasion; hand2 as1; hand2 ... See more keywords
HAND transcription factors cooperatively specify the aorta and pulmonary trunk.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental biology"
DOI: 10.1016/j.ydbio.2021.03.011
Abstract: Congenital heart defects (CHDs) affecting the cardiac outflow tract (OFT) constitute a significant cause of morbidity and mortality. The OFT develops from migratory cell populations which include the cardiac neural crest cells (cNCCs) and secondary… read more here.
Keywords: transcription; hand; hand1 hand2; hand2 ... See more keywords
Long Noncoding RNA HAND2-AS1 Suppresses Cell Proliferation, Migration, and Invasion of Bladder Cancer via miR-17-5p/KLF9 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2021.0637
Abstract: Bladder cancer (BC) is the most common type of malignant tumor in the genitourinary system. Through the microarray analysis of clinical samples, long noncoding RNA HAND2-AS1 expression was found to be downregulated in BC tissues.… read more here.
Keywords: hand2 as1; cell; hand2; mir klf9 ... See more keywords
The adult heart requires baseline expression of the transcription factor Hand2 to withstand RV pressure overload.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab299
Abstract: AIMS Research on the pathophysiology of right ventricular (RV) failure has, in spite of the associated high mortality and morbidity, lagged behind compared to the left ventricle (LV).Previous work from our lab revealed that the… read more here.
Keywords: pressure overload; expression; hand2; failure ... See more keywords
Regulation of HAND2 Expression by LncRNA HAND2-AS1 in Ovarian Endometriosis Involving DNA Methylation
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvad049
Abstract: Abstract HAND2 is a critical mediator of progesterone receptor signaling in endometrium. Silencing of HAND2 expression is associated with female infertility and endometrial cancers. We recently observed that lncRNA HAND2-AS1 and HAND2 are expressed coordinately… read more here.
Keywords: hand2 as1; methylation; hand2; hand2 expression ... See more keywords
NONO enhances mRNA processing of super‐enhancer‐associated GATA2 and HAND2 genes in neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202254977
Abstract: High‐risk neuroblastoma patients have poor survival rates and require better therapeutic options. High expression of a multifunctional DNA and RNA‐binding protein, NONO, in neuroblastoma is associated with poor patient outcome; however, there is little understanding… read more here.
Keywords: rna binding; hand2; activity; enhancer associated ... See more keywords
osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10112868
Abstract: Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of congenital malformations of the kidney. The transcription factors Osr1 and Hand2 are known to exert antagonistic influences to… read more here.
Keywords: podocyte development; antagonism; development; wnt2ba ... See more keywords