Sustainable HandaPhos-ppm Palladium Technology for Copper-Free Sonogashira Couplings in Water under Mild Conditions.
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DOI: 10.1021/acs.orglett.7b03621
Abstract: Complexation of ca. 1000 ppm Pd(OAc)2 with the ligand HandaPhos (1-1.5:1) leads to a precatalyst that efficiently mediates Sonogashira couplings in aqueous nanomicelles under very mild conditions. Neither copper nor organic solvent is required in… read more here.
Keywords: sustainable handaphos; mild conditions; copper; handaphos ppm ... See more keywords