Kidney ion handling genes and their interaction in blood pressure control
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DOI: 10.1042/bsr20220977
Abstract: Abstract Hypertension affects 30% of adults and is the leading risk factor for cardiovascular disease. Kidney sodium reabsorption plays a vital role in the initial stage and development of essential hypertension. It has been extensively… read more here.
Keywords: handling genes; kidney ion; blood; ion handling ... See more keywords
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes
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DOI: 10.1101/2022.03.15.484462
Abstract: Experimental inactivation of certain genes involved in metabolism attenuates cancer cell growth in vitro. However, loss-of-function mutations in metabolic pathways are not negatively selected in human cancers, indicating that these genes are not essential in… read more here.
Keywords: handling genes; solute exchange; exchange gap; gap junctions ... See more keywords
MED12 regulates a transcriptional network of calcium-handling genes in the heart.
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DOI: 10.1172/jci.insight.91920
Abstract: The Mediator complex regulates gene transcription by linking basal transcriptional machinery with DNA-bound transcription factors. The activity of the Mediator complex is mainly controlled by a kinase submodule that is composed of 4 proteins, including… read more here.
Keywords: transcription; heart; handling genes; calcium handling ... See more keywords