Inactivation of Human Aldehyde Oxidase by Small Sulfhydryl-Containing Reducing Agents
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001244
Abstract: Human aldehyde oxidase (hAOX1) is a molybdoflavoenzyme that belongs to the xanthine oxidase (XO) family. hAOX1 is involved in phase I drug metabolism, but its physiologic role is not fully understood to date, and preclinical… read more here.
Keywords: aldehyde oxidase; sulfhydryl; sulfhydryl containing; human aldehyde ... See more keywords
A single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0182061
Abstract: Aldehyde oxidases (AOXs) are molybdo-flavoenzymes characterized by broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into the corresponding carboxylic acids and hydroxylating various heteroaromatic rings. The enzymes use oxygen as the terminal electron acceptor and produce reduced… read more here.
Keywords: amino acid; production; oxygen species; single nucleotide ... See more keywords